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Method for treating mucositis

a technology for mucositis and mucosa, which is applied in the field of preventing or treating mucositis, can solve the problems of affecting the quality of life of patients, affecting the need for total parenteral nutrition, and the mucosal lining of the alimentary track becomes thin, so as to prevent or treat mucositis

Active Publication Date: 2017-05-11
ENZYCHEM LIFESCI CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention aims to provide a novel solution for a specific technical problem. The technical effects of the patent text will be provided in detail to allow for a better understanding of the invention. It should be noted that the details described herein are only meant to show certain preferred ways of implementing the invention. The goal of the patent text is to provide a solution that can be applied in various settings and can address different needs.

Problems solved by technology

As a result of cell death in reaction to chemotherapy, the mucosal lining of the alimentary track such as the mouth becomes thin, may be inflamed and ulcerated.
Treatment-induced mucositis is one of the most debilitating and troublesome side effects from cancer therapy and affects quality of patient's life.
In severe cases, the patient is unable to eat the solid food and even unable to consume liquids as well, resulting in the need for total parenteral nutrition (TPN).
As a result, mucositis is associated with considerable morbidity, diminished quality of life as well as negative health and economic outcomes.
In addition, mucositis may interfere with the regular administration and dosing of programmed treatment plans, thus affecting the outcome of cancer treatment.
It is also known that hot food, wound in the mouth, fatigue or allergy may cause aphthous stomatitis or exacerbate it.
SLE may also cause joint pain, kidney problems and depression.
Currently, no approved preventive or therapeutic agent consistently prevents mucositis in all clinical settings.
However, the measures to prevent or treat mucositis are inadequate and limited to the control of pain, infections, bleeding and nutrition.

Method used

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  • Method for treating mucositis
  • Method for treating mucositis
  • Method for treating mucositis

Examples

Experimental program
Comparison scheme
Effect test

example 1

ffect of PLAG on Oral Ulceration

[0081]Total 44 patients with recurrent oral ulceration (ROU) between 20 and 80 years old (34 female patients and 10 male patients, Disease; RAS (26 patients), BD (27 patients), SLE (1 patient), Mean age: 49.3±9.0) were enrolled in the study. The diagnosis of ROU was made based upon the history and the physical examination on oral mucosa by physicians. We included three conditions with recurrent oral ulceration: Recurrent aphthous stomatitis (RAS), Behcet's disease (BD), Systemic lupus erythematosus (SLE). After completing baseline assessments, 250 mg of PLAG was administered to the patients orally twice a day (250 mg PLAG per tablet, 500 mg / day) for 2-4 weeks. The change of recurrent oral ulcer in the patients was evaluated at 2 or 4 weeks after the treatment by using self-reported scoring system (total 12 points), including the following three measurements: change of ulcer frequency (Likert 0-4), Change of ulcer severity: pain & size (Likert 0-4) and...

example 2

ge Formulation

[0083]An exemplary soft gelatin capsule for use in the methods described herein, containing (i) PLAG and (ii) α-tocopherol, is prepared, having a composition as follows:

TABLE 2Composition of PLAG Softgel CapsulesComponentFunctionUnit FormulaPLAGActive Ingredient250.0 or 500.0 mgα-tocopherolAnti-oxidant1.0 mg

TABLE 3Composition of Soft Capsule ShellsIngredientsFunctionGelatinCapsule shellConcentrated glycerinPlasticizerMethyl para-oxybenzoatePreservativePropyl para-oxybenzoatePreservativeEthyl vanillinFlavorTitanium dioxideColorantTar color, MFDS notified Blue No. 1ColorantTar color, MFDS notified Red No. 40ColorantTar color, MFDS notified Yellow No. 203ColorantPurified waterVehicle

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Abstract

The invention provides a pharmaceutical composition for preventing or treating mucositis, for example oral mucositis (e.g., oral ulceration) and gastrointestinal mucositis, comprising a monoacetyldiacylglycerol compound, especially PLAG, and a method of preventing or treating mucositis using the same.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application claims priority from U.S. Provisional 62 / 253,019, filed 9 Nov. 2015, the content of which is incorporated herein by reference.FIELD OF THE INVENTION[0002]The invention relates to methods for preventing or treating mucositis, for example oral mucositis (e.g., oral ulceration) and gastrointestinal mucositis, comprising administration of a monoacetyldiacylglycerol compound, as well as compositions, more particularly, pharmaceutical compositions and health functional food compositions, useful therefor.BACKGROUND OF THE INVENTION[0003]Mucositis is a pathological condition characterized by mucosal damage, ranging from mild inflammation to deep ulcerations and affecting one or more parts of the alimentary tract from the mouth to the anus. Mucositis usually occurs as an adverse effect of treatment of diseases such as cancer. As a result of cell death in reaction to chemotherapy, the mucosal lining of the alimentary track such as ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/231A61N5/06A61K9/48A61K45/06A61K9/00
CPCA61K31/231A61K45/06A61K9/0053A61N2005/067A61K9/4858A61N5/0603A61N2005/0606A61K9/4825A61N2005/0609A61P1/02A61P1/04A61P29/00A61N5/067A61K9/48A61K31/22A61K31/355A61K31/375
Inventor SOHN, KI-YOUNG
Owner ENZYCHEM LIFESCI CORP
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