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Coagulation Factor-Targeting to TLT-1 on Activated Platelets

a coagulation factor and activated platelet technology, applied in the field of procoagulant proteins and polynucleotides, can solve the problems of threatening bleeding, spontaneous bleeds, and dysfunctional coagulation cascade steps

Inactive Publication Date: 2016-09-15
NOVO NORDISK HEALTH CARE AG
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In subjects with a coagulopathy, such as human beings with haemophilia A, B or C, various steps of the coagulation cascade are rendered dysfunctional due to, for example, the absence or insufficient presence of a functional coagulation factor.
Such dysfunction of one part of coagulation results in insufficient blood coagulation leading to spontaneous bleeds e.g. in joints and potentially life-threatening bleeding.

Method used

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  • Coagulation Factor-Targeting to TLT-1 on Activated Platelets
  • Coagulation Factor-Targeting to TLT-1 on Activated Platelets
  • Coagulation Factor-Targeting to TLT-1 on Activated Platelets

Examples

Experimental program
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Effect test

embodiment 1

[0361]A procoagulant protein comprising (i) at least one coagulation factor, covalently attached to (ii) an antibody, or fragment thereof, that is capable of binding (iii) TLT-1, and / or a fragment or variant thereof.

embodiment 2

[0362]The procoagulant protein according to embodiment 1, wherein (iii) is TLT-1, or a fragment or variant thereof.

embodiment 3

[0363]The procoagulant protein according to embodiment 2, wherein (iii) is TLT-1 (16-162).

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Abstract

The current invention relates to: procoagulant proteins which may, for example, be fusion proteins or chemical conjugates; methods of producing said procoagulant proteins; polynucleotides that encode said fusion proteins and cells that expresses them. Furthermore, the current invention relates to procoagulant proteins for use as a medicament. Individuals that have a coagulopathy, such as haemophilia A and B with or without inhibitors, may be treated with the procoagulant proteins of the current invention.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a continuation of U.S. application Ser. No. 13 / 982,360 filed Jul. 29, 2013 which is a 35 U.S.C. §371 National Stage application of International Application PCT / EP2012 / 053619 (WO 2012 / 117091 A1), filed Mar. 2, 2012, which claimed priority of European Patent Application 11156682.4, filed Mar. 2, 2011; this application claims priority under 35 U.S.C. §119 of U.S. Provisional Application 61 / 449,254; filed Mar. 4, 2011; the contents of all above-mentioned applications are incorporated herein by reference.FIELD OF THE INVENTION[0002]The current invention relates to procoagulant proteins, polynucleotides that encode procoagulant fusion proteins, cells that express procoagulant fusion proteins, a process for preparing procoagulant proteins and uses of said procoagulant proteins.INCORPORATION-BY-REFERENCE OF THE SEQUENCE LISTING[0003]In accordance with 37 C.F.R. §1.52(e)(5), Applicants enclose herewith the Sequence Listing for...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K47/48C12N9/96C12N9/64C07K16/28A61K38/48
CPCA61K47/4843C07K2319/21A61K38/4846A61K47/48561C12N9/6437C12N9/96C12Y304/21021C07K2317/55C07K2317/24C07K2317/21C07K2317/92C07K2317/41C07K2317/56C07K2317/51C07K2317/515C07K2319/00C07K16/2803C07K2299/00C07K2317/34A61K38/00C07K14/4703C12Y304/21022C12N9/644C07K14/745A61K47/6815A61K47/6849A61P7/04A61K38/36
Inventor HILDEN, IDAPESCHKE, BERNDBREINHOLT, JENSKOFOD-HANSEN, MIKAEL
Owner NOVO NORDISK HEALTH CARE AG
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