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Methods of inducing and preventing neurofibromatosis in schwann cells

a neurofibromatosis and schwann cell technology, applied in the field of neurofibromatosis type 2 therapy targets, can solve the problems of headache, vertigo, balance problems, etc., and achieve the effect of effectively inactivating the activity of schwannomin's tumor suppressor

Inactive Publication Date: 2016-06-23
UNIV OF CENT FLORIDA RES FOUND INC
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  • Abstract
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Benefits of technology

[0012]The method comprises contacting the cells with laminin-1 so as to bind α6β1 integrin sufficiently to activate endogenous kinase Cdc42-Pak; and, in response, phosphorylating Schwannomin-S518 in the cells by the activated kinase, effectively inactivating Schwannomin's tumor suppressor activity and allowing proliferation of subconfluent Schwann cells, thereby modeling NF2.

Problems solved by technology

The tumors may cause headache, balance problems, and Vertigo, facial weakness / paralysis.

Method used

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  • Methods of inducing and preventing neurofibromatosis in schwann cells
  • Methods of inducing and preventing neurofibromatosis in schwann cells
  • Methods of inducing and preventing neurofibromatosis in schwann cells

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Embodiment Construction

[0024]The present invention will now be described more fully hereinafter with reference to the accompanying drawings, in which preferred embodiments of the invention are shown. Unless otherwise defined, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention pertains. Although methods and materials similar or equivalent to those described herein can be used in the practice or testing of the present invention, suitable methods and materials are described below. Any publications, patent applications, patents, or other references mentioned herein are incorporated by reference in their entirety. In case of conflict, the present specification, including any definitions, will control. In addition, the materials, methods and examples given are illustrative in nature only and not intended to be limiting. Accordingly, this invention may be embodied in different forms and should not be construed as...

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Abstract

The invention provides a method of inducing neurofibromatosis type 2 (NF2) in Schwann cells. The method comprises contacting the cells with laminin-1 so as to bind α6β1 integrin sufficiently to activate endogenous kinase Cdc42-Pak; and phosphorylating Schwannomin-S518 in the cells by the activated kinase, effectively inactivating. Schwannomin's tumor suppressor activity and allowing proliferation of subconfluent Schwann cells, thereby modeling NF2. The invention also includes a method of preventing a Schwann cell from forming a tumor by contacting the cell with an amount of tyrphostin AG825 sufficient to inhibit a receptor selected from ErB2, ErB3, β1 integrins and combinations thereof, so as to prevent phosphorylation of Schwannomin-S815 by one or more endogenous kinases.

Description

RELATED APPLICATION[0001]This application claims priority from co-pending provisional applications Ser. No. 60 / 946,782, which was filed on 28 Jun. 2007, and Ser. No. 60 / 955,141, which was filed on 10 Aug. 2007, both of which are incorporated herein by reference in their entirety.STATEMENT OF GOVERNMENT RIGHTS[0002]The work leading to this application was supported at least in part by a grant from the Department of Defense. Accordingly, the government may have certain rights in the invention, as specified by law.FIELD OF THE INVENTION[0003]This invention relates to the field of neurobiology and, more specifically, to therapeutic targets for treatment of neurofibromatosis type 2 (NF2).BACKGROUND OF THE INVENTION[0004]Neurofibromatosis is an autosomal dominant genetic disorder. It encompasses a set of distinct genetic disorders that cause tumors to grow along types of nerves and, in addition, can affect the development of non-nervous tissues such as bones and skin. The tumors can grow ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12N5/079
CPCC12N5/0622C12N2501/998C12N2501/13A61K31/43
Inventor FERNANDEZ-VALLE, CRISTINATHAXTON, COURTNEYLOPERA, JORGEBOTT, MARGA
Owner UNIV OF CENT FLORIDA RES FOUND INC
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