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Compositions and methods for the treatment of metabolic syndrome

a metabolic syndrome and composition technology, applied in the direction of biocide, plant growth regulators, pharmaceutical non-active ingredients, etc., can solve the problems of significant morbidity and mortality at considerable expense for patients, their families and society

Active Publication Date: 2016-05-05
CELLIXBIO PTE LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The compositions effectively treat and prevent metabolic syndrome and its complications by providing a therapeutically effective amount of the active compounds, thereby addressing insulin resistance, glucose intolerance, and other associated disorders.

Problems solved by technology

This disease causes significant morbidity and mortality at considerable expense to patients, their families and society.

Method used

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  • Compositions and methods for the treatment of metabolic syndrome
  • Compositions and methods for the treatment of metabolic syndrome
  • Compositions and methods for the treatment of metabolic syndrome

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Definitions

[0026]As used herein, the following terms and phrases shall have the meanings set forth below. Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood to one of ordinary skill in the art.

[0027]The compounds of the present invention can be present in the form of pharmaceutically acceptable salts. The compounds of the present invention can also be present in the form of pharmaceutically acceptable esters (i.e., the methyl and ethyl esters of the acids of formula I to be used as prodrugs). The compounds of the present invention can also be solvated, i.e. hydrated. The solvation can be affected in the course of the manufacturing process or can take place i.e. as a consequence of hygroscopic properties of an initially anhydrous compound of formula I (hydration).

[0028]Compounds that have the same molecular formula but differ in the nature or sequence of bonding of their atoms or the arrangement of their atoms in spac...

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Abstract

The invention relates to the compounds of formula I or its pharmaceutical acceptable salts, as well as polymorphs, solvates, enantiomers, stereoisomers and hydrates thereof. The pharmaceutical compositions comprising an effective amount of compounds of formula I, and methods for the treatment of metabolic syndrome may be formulated for oral, buccal, rectal, topical, transdermal, transmucosal, intravenous, parenteral administration, syrup, or injection. Such compositions may be used to treatment of hyperuricemia, gout, dyslipidemia, obesity, urea cycle disorders, hyperglycemia, insulin resistance, diabetes mellitus, diabetes insipidus, type 1 diabetes, type 2 diabetes, microvascular complications, macrovascular complications, lipid disorders, prediabetes, obesity, arrhythmia, myocardial infarction, stroke, neuropathy, renal complications, hypertriglyceridemia, cardiovascular complications, and post prandial hyperglycemia.

Description

PRIORITY[0001]This application is a national phase filing of the Patent Cooperation Treaty (PCT) application # PCT / IB2013 / 050904 titled COMPOSITIONS AND METHODS FOR THE TREATMENT OF METABOLIC SYNDROME filed on Feb. 3, 2013 Published with WIPO Publication # WO / 2013 / 167996, which further claims priority to patent application 1835 / CHE / 2012 filed on May 10, 2012 in the country of India. The entire disclosure of the priority applications are relied on for all purposes and is incorporated into this application by reference.FIELD OF THE INVENTION[0002]This disclosure generally relates to compounds and compositions for the treatment of metabolic syndrome. More particularly, this invention relates to treating subjects with a pharmaceutically acceptable dose of compounds, crystals, solvates, enantiomer or stereoisomer, esters, salts, hydrates, prodrugs, or mixtures thereof.BACKGROUND OF THE INVENTION[0003]The multifaceted metabolic syndrome is defined as a number of major metabolic disorders ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C07C69/736A61K31/24C07C233/49A61K31/235A61K47/48
CPCC07C69/736A61K31/235A61K31/24C07C233/49A61K47/48038C07C233/20
Inventor KANDULA, MAHESH
Owner CELLIXBIO PTE LTD
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