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Delivery of gases to the nasal airway

a technology for nasal airway and gas delivery, which is applied in the direction of oxygen respirator, other medical devices, life-saving devices, etc., can solve the problems of problematic delivery of therapeutic gases to the nasal airway, and achieve the effect of enhancing uptake of active substances

Inactive Publication Date: 2015-04-02
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

The present invention aims to provide a device and method for delivering gases to the nasal airway in a safe and effective way. The device can deliver therapeutic gases at higher concentrations without the risk of inhalation. Additionally, the invention provides a method of enhancing the uptake of a substance into the nasal airway by supplying a substance and an uptake enhancing gas to the nasal airway of a subject. This can be done through a nasal piece fitted to one nostril of the subject.

Problems solved by technology

As noted in WO-A-2001 / 003645, the delivery of therapeutic gases to the nasal airway is problematic, insofar as delivery of the gases to the nasal airway leads to inhalation of the gases.

Method used

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  • Delivery of gases to the nasal airway
  • Delivery of gases to the nasal airway
  • Delivery of gases to the nasal airway

Examples

Experimental program
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first embodiment

[0274]FIG. 1 illustrates a delivery device in accordance with the present invention.

[0275]The delivery device comprises a nosepiece 21 for fitting in one nostril of a subject, in this embodiment to provide a fluid-tight seal therewith, a mouthpiece 23 through which the subject exhales, and a flow channel 25 fluidly connecting the nosepiece 21 and the mouthpiece 23.

[0276]The delivery device further comprises a scrubber 27 which is disposed in the flow channel 25 such as to remove one or more gases, in this embodiment one or both of oxygen and nitrogen, from the exhaled air and provide a gas flow which has an increased concentration of at least one gas, in this embodiment a concentration of carbon dioxide, which is increased to a concentration which provides a therapeutic effect.

[0277]Alveolar air typically has a composition of N2—74.9 vol %, O2—13.6 vol % and CO2 —5.3 vol %, which has a significantly increased concentration of carbon dioxide as compared to atmospheric air, which typi...

second embodiment

[0281]FIG. 2 illustrates a delivery device in accordance with the present invention.

[0282]The delivery device comprises a nosepiece 121 for fitting in one nostril of a subject, in this embodiment to provide a fluid-tight seal therewith, a mouthpiece 123 through which the subject exhales, and a flow channel 125 fluidly connecting the nosepiece 121 and the mouthpiece 123.

[0283]The delivery device further comprises a scrubber 127 which is disposed in the flow channel 125 such as to remove one or more gases, in this embodiment one or both of oxygen and nitrogen, from the exhaled air and provide a gas flow which has an increased concentration of at least one gas, in this embodiment a concentration of carbon dioxide, which provides for enhanced uptake of a substance as delivered to the nasal airway, as will be described in more detail hereinbelow.

[0284]Alveolar air typically has a composition of N2—74.9 vol %, O2—13.6 vol % and CO2—5.3 vol %, which has a significantly increased concentrat...

third embodiment

[0297]FIG. 3 illustrates a delivery device in accordance with the present invention.

[0298]The delivery device comprises a nosepiece 221 for fitting in one nostril of a subject, in this embodiment to provide a fluid-tight seal therewith, a mouthpiece 223 through which the subject exhales, and a flow channel 225 fluidly connecting the nosepiece 221 and the mouthpiece 223.

[0299]The delivery device further comprises a gas generation unit 227 which is disposed in the flow channel 225 and provides for the generation of a therapeutic gas, in this embodiment carbon dioxide, which is entrained by the gas flow, as developed by the exhalation breath, into the nasal airway, and thereby provides a therapeutic effect on delivery into the nasal airway.

[0300]In this embodiment the gas generation unit 227 contains a powdered agent, here a mixture of a carbonate or bicarbonate salt, such as sodium bicarbonate, and an acid, such as citric acid, which, when exposed to moisture as contained in the exhal...

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Abstract

A delivery device for and a method of delivering gases to the nasal airway, in particular therapeutic gases and gases in combination with active substances, either as powders or liquids, for enhanced uptake of the active substances.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS[0001]This application is a Continuation of U.S. patent application Ser. No. 12 / 375,115, filed on Apr. 23, 2010, which is a U.S. National phase application of PCT / GB2007 / 002829 filed Jul. 25, 2007, the disclosure of which applications are incorporated herein by reference.FIELD OF INVENTION[0002]The present invention relates to a device for and a method of delivering gases to the nasal airway, in particular therapeutic gases and gases in combination with active substances, either as powders or liquids, for enhanced uptake of the active substances.BACKGROUND[0003]The delivery of gases, in particular carbon dioxide, nitric oxide, oxygen and helium, to the nasal airway for therapeutic application is known, as disclosed, for example, in WO-A-2001 / 003645.[0004]Gas therapy for the treatment of headaches, allergies, asthma, and other conditions as well as associated physiology is described in the following references in the medical literature:[0005]Car...

Claims

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Application Information

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IPC IPC(8): A61M16/06A61M16/22A61M16/12A61M16/10A61M16/00
CPCA61M16/0672A61M16/101A61M16/0003A61M16/0057A61M16/122A61M16/22A61M2202/025A61M2016/003A61M2202/0208A61M2202/0225A61M2202/0266A61M2202/064A61M2205/3334A61M2016/0027A61M15/0028A61M15/08A61M16/0808A61M2016/0021A61M2016/0042A61M2202/0275A61M2210/0625A61M15/0003A61M15/0098A61M15/025A61M16/142A61M15/0065
Inventor DJUPESLAND, PER GISLEHAFNER, RODERICK PETER
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