Analgesic medication

a technology of analgesic medication and acetate, which is applied in the direction of drug composition, nervous disorder, biochemistry apparatus and processes, etc., can solve the problems of insomnia, muscle and bone pain, and long-term use of interferon- may develop plenty of side effects, and achieves insomnia, weight loss, and poor appeti

Inactive Publication Date: 2013-12-12
I-SHOU UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0008]It is therefore the objective of this invention to provide an analgesic medication, which can induce a-interferon response, to achieve analgesic effects or pain relief without leading to the said side effects.

Problems solved by technology

However, a long-term use of interferon-α may develop plenty side effects, such as fever, chili, muscle and bone pains, insomnia, poor appetites, weight loss, and fatigue.
Although those side effects will not result in serious damages or complications, people still suffer from uncomfortableness and inconvenience in daily life.
Under such circumstance, industrial produced interferon-α is limited in practical use, especially in a development of analgesic medication or analgesic treatment.

Method used

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Examples

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Embodiment Construction

[0022]A preferable embodiment of the present invention relates to an analgesic medication comprising an isolated oligonucleotide. The oligonucleotide is a double strand RNA comprising nucleotide sequences that is or is not homologous to organism genes. The oligonucleotide has 18 to 70 base pairs, preferably 18 to 25 base pairs, or 40 to 60 base pairs, to induce interferon-α response in hosts. The oligonucleotide is combined with a pharmaceutical acceptable vehicle, such as polyethyleneimine (PEI), lipofectamineand iFect, preferably with PEI and in a ratio of 0.18 μl PEI: 1 μg oligonucleotide, so that the oligonucleotide can be successfully delivered to cells in central nervous system.

[0023]When delivering the said oligonucleotide in an individual (a rat or human body), the said oligonucleotide can induce interferon-α response, to achieve reversible analgesic effects in central or peripheral nervous systems via μ-opioid receptor.

[0024]Furthermore, in a preferable embodiment of the pr...

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Abstract

An analgesic medication includes an oligonucleotide being a double strand RNA comprising 18 to 70 base pairs, and a pharmaceutical acceptable vehicle for delivering the said oligonucleotide into cells, wherein a dosage of the oligonucleotide in the analgesic is 50 μg to 200 μg/kg per time, and the pharmaceutical acceptable vehicle is selected from a group of polyethyleneimine, lipofectamine and iFect.

Description

BACKGROUND OF THE INVENTION[0001]1. Field of the Invention[0002]The present invention generally relates to an analgesic medication, and, more particularly, to an analgesic medication comprising oligonucleotides capable of inducing interferon response and analgesic effects.[0003]2. Description of the Related Art[0004]Interferons (IFNs) are proteins made and released by host cells in response to viruses or other pathogens infection, which can trigger protective defenses of immune system, interfering replication of virus (or other pathogens) and proliferation of host cell, so as to reduce or avoid adjacent host cells being further infected by virus or pathogens.[0005]Interferons found in human body are typically divided into two classes: class I, primary comprising interferon-α and interferon-β (also comprising interferon-α, interferon-ω, interferon-τ, interferon-δ, interferon-κ, and interferon-ε); and class II, comprising interferon-γ. Recent studies showed that interferon-γ is produc...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K31/713A61P29/00
CPCA61K9/0019A61K31/713A61P25/04A61P29/00
Inventor TAN, PING-HENG
Owner I-SHOU UNIVERSITY
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