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Protection of Progenitor Cells and Regulation of Their Differentiation

a technology for progenitor cells and differentiation, applied in the field of progenitor cell protection and differentiation regulation, can solve the problems of less developed technology for non-haematopoietic-type adult progenitor cells, and achieve the effect of enhancing cryopreservation and improving the viability of progenitor cells

Inactive Publication Date: 2011-01-20
PROTEOBIOACTIVES PTY LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

"The present invention provides a composition that includes progenitor cells and a polysulfated polysaccharide or biologically active molecular fragment thereof. The polysulfated polysaccharide can enhance the viability of the progenitor cells after cryopreservation and can regulate the differentiation of the cells. It can also be used to treat injuries and degenerative diseases such as osteoarthritis. The composition can be used in both in vitro and in vivo methods. The polysulfated polysaccharide can induce chondrogenesis, the regeneration of cartilage and intervertebral discs. The invention opens up new treatment avenues for these conditions. The concentration of the polysulfated polysaccharide in the composition can vary depending on the number of cells."

Problems solved by technology

However, technology related to non-haematopoietic-type adult progenitor cells is much less developed due to the difficulty of obtaining sufficient numbers of these cells and of growing them in the laboratory.

Method used

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  • Protection of Progenitor Cells and Regulation of Their Differentiation
  • Protection of Progenitor Cells and Regulation of Their Differentiation
  • Protection of Progenitor Cells and Regulation of Their Differentiation

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Embodiment Construction

[0222]As used in the specification and claims, the singular form “a”, “an” and “the” include plural references unless the context clearly dictates otherwise. For example, the term “a polypeptide” includes a plurality of polypeptides, including mixtures thereof.

[0223]As used herein the term “derived from” shall be taken to indicate that a specified integer are obtained from a particular source albeit not necessarily directly from that source.

[0224]A “composition” is intended to mean a combination of active agent and another compound or composition, inert (for example, a detectable agent or label) or active, such as an adjuvant.

[0225]Unless the context requires otherwise or specifically stated to the contrary, integers, steps, or elements of the invention recited herein as singular integers, steps or elements clearly encompass both singular and plural forms of the recited integers, steps or elements.

[0226]The embodiments of the invention described herein with respect to any single emb...

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Abstract

The present invention relates to the use of polysulfated polysaccharides in combination with progenitor cells to improve the viability of the progenitor cells including improving the cryopreservation of the progenitor cells and provides novel compositions, methods and uses. The present invention also relates to the use of polysulfated polysaccharides to regulate the proliferation and differentiation of progenitor cells.

Description

FIELD OF THE INVENTION[0001]The present invention relates to the use of polysulfated polysaccharides in combination with progenitor cells to improve the viability of the progenitor cells including improving the cryopreservation of the progenitor cells and provides novel compositions, methods and uses. The present invention also relates to the use of polysulfated polysaccharides to regulate the proliferation and differentiation of progenitor cells.BACKGROUND OF THE INVENTION[0002]Human progenitor cells are the immature cells that give rise to all of the different types of mature cells that make up the organs and tissues of the adult body. The transition from progenitor cell to mature, specialised adult cell is via a process called differentiation.[0003]Progenitor cells in the body take different pathways of differentiation in response to different stimuli from their environment. Similarly, progenitor cells in the laboratory can be stimulated to differentiate along different pathways ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): C12N5/07A61K35/12C12N5/077C12N5/0775
CPCA61K35/12A01N1/0226C12N2501/90C12N5/0663A61K31/737A61P19/02A61P19/08A01N1/0221C12N5/0662A61K35/28C12N5/0655C12N2506/1346
Inventor GHOSH, PETER
Owner PROTEOBIOACTIVES PTY LTD
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