Vitamin k for prevention and treatment of skin rash secondary to Anti-egfr therapy
a technology of vitamin k and skin rash, applied in the field of vitamin k for preventing and treating skin rash secondary to anti-egfr therapy, can solve the problems of poor or inconsistent, no rational, scientifically proven and clinically effective methods available for the treatment of this form of skin rash, and unfavorable cosmetic changes, so as to prevent skin rash, prevent skin rash, and treat skin rash.
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[0025]The present invention is directed to a method for treating a skin rash secondary to an anti-epidermal growth factor receptor (EGFR) therapy in a subject receiving said therapy, the method comprising applying a vitamin K analog to the skin rash in an amount effective to treat the skin rash.
[0026]As used herein, the term “treat” a skin rash secondary to anti-EGFR therapy means to reduce or eliminate the skin rash, and / or to decrease or eliminate the increase or spread of the skin rash on the subject's skin.
[0027]Subjects receiving anti-EGFR therapy include patients receiving treatment with an anti-EGFR antibody such as cetuximab and / or with an EGFR tyrosine kinase inhibitor such as gefitinib or erlotinib.
[0028]As used herein, a “vitamin K analog” is a compound selected from the group consisting of vitamin K1 (2-methyl-3-phytyl-1,4-naphthoquinone), vitamin K2 (2-methyl-3-hexaprenyl-1,4-naphthoquinone; menaquinone), vitamin K3 (2-methyl-1,4-naphthoquinone; menadione), vitamin K4 (...
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