System and Methods for Determination of Analyte Concentration Using Time Resolved Amperometry

Abstract

This invention is a method for determining a concentration of an analyte. The steps include applying a potential excitation to a fluid sample containing an analyte, and measuring one or more currents associated with one or more time-segments. The method can also include calculating a final analyte concentration based on a first and second set of analyte concentrations, wherein each set of analyte concentration values is based on a first and second set of calibration data associated with first and second time-segments.

Description

[0001]This application claims priority to U.S. Provisional Patent Application No. 60 / 952,076, filed Jul. 26, 2007, which is incorporated herein by reference in its entirety.DESCRIPTION OF THE INVENTION[0002]1. Field of the Invention[0003]The present invention relates to the field of diagnostic testing systems for determining the concentration of an analyte in a solution and, more particularly, to systems and methods for measuring an analyte concentration using interpolate time resolved amperometry.[0004]2. Background of the Invention[0005]The present disclosure relates to a biosensor system for measuring an analyte in a bodily fluid, such as blood. The system includes a process and system for improved determination of analyte concentration over a wide range of analyte concentrations.[0006]Electrochemical sensors have long been used to detect or measure the presence of substances in fluid samples. Electrochemical sensors include a reagent mixture containing at least an electron trans...

AI Technical Summary

Benefits of technology

"This patent describes methods and systems for accurately determining the concentration of an analyte in a fluid sample. The invention uses multiple sets of calibration data that converge over time, taking into account the different matrix components of the sample. The method involves applying a potential excitation to the sample, measuring the current during two time-segments, and calculating the analyte concentration based on the measured current and the associated calibration data. The system includes electrodes and a processor for measuring the current and calculating the analyte concentration. The invention can provide more accurate results even when the analyte concentration is low."

Problems solved by technology

However, these calibration data were found to converge over time under certain conditions.

Images