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Non-Invasive In Vivo Imaging and Methods for Treating Type I Diabetes

Inactive Publication Date: 2009-03-05
BIOCRINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Benefits of technology

[0008]In another aspect, the present invention provides methods for treating a subject with type I diabetes, comprising transplanting int

Problems solved by technology

However, results obtained from experiments in vitro are often not sufficient to explain the performance of cells in more physiological settings like whole organs or living organisms.
Unfortunately, non-invasive imaging techniques like computer tomography (CT), magnet resonance imaging (MRI), positron emission tomography (PET) or bioluminescence imaging (BLI) lack cellular resolution.
Accessing target cells for the application of LSM is mostly invasive and often excludes the possibility of repetitive examinations.

Method used

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  • Non-Invasive In Vivo Imaging and Methods for Treating Type I Diabetes

Examples

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example 1

REFERENCES FOR EXAMPLE 1

[0052]1. Wajchenberg, B. L. Beta-Cell Failure in Diabetes and Preservation by Clinical Treatment. Endocr Rev (2007).[0053]2. Berggren, P. O. & Leibiger, I. B. Novel aspects on signal-transduction in the pancreatic beta-cell. Nutr Metab Cardiovasc Dis 16 Suppl 1, S7-10 (2006).[0054]3. Vetterlein, F., Petho, A. & Schmidt, G. Morphometric investigation of the microvascular system of pancreatic exocrine and endocrine tissue in the rat. Microvasc Res 34, 231-8 (1987).[0055]4. Woods, S. C. & Porte, D., Jr. Neural control of the endocrine pancreas. Physiol Rev 54, 596-619 (1974).[0056]5. Rahier, J., Goebbels, R. M. & Henquin, J. C. Cellular composition of the human diabetic pancreas. Diabetologia 24, 366-71 (1983).[0057]6. Köhler, M. et al. Imaging of Pancreatic Beta-Cell Signal-Transduction. Curr. Med. Chem.-Immun., Endoc. &Metab. Agents 4, 281-299 (2004).[0058]7. Speier, S. & Rupnik, M. A novel approach to in situ characterization of pancreatic beta-cells. Pfluger...

example 2

[0080]In this example, we provide a step-by-step protocol for non-invasive longitudinal in vivo studies of cell biology at single-cell resolution, taking advantage of the cornea as a natural body window. For this purpose, the tissue of interest is transplanted into the anterior chamber of the eye and cell biological parameters are assessed by LSM through the cornea. The anterior chamber of the eye has been frequently used as a transplantation site to study a variety of tissues3-7. While originally the anterior chamber of the eye was selected as a transplantation site because of its properties as an immune privileged site8, most studies utilized the anterior chamber in a syngeneic transplantation setting because it is easily accessible and the cornea allows macroscopic observation of the engrafted tissue. Additionally, the iris, which forms the base of the anterior chamber, has one of the highest concentrations of blood vessels and autonomic nerves in the body, and thereby enables fa...

example 2 references

[0230]1. Koo, V., Hamilton, P. W. & Williamson, K. Non-invasive in vivo imaging in small animal research. Cell Oncol 28, 127-139 (2006).[0231]2. Handbook of biological confocal microscopy, Edn. 3 (Pawley, J. B.) (Springer, New York, N.Y., 2005).[0232]3. Adeghate, E., Ponery, A. S., Ahmed, I. & Donath, T. Comparative morphology and biochemistry of pancreatic tissue fragments transplanted into the anterior eye chamber and subcutaneous regions of the rat. European journal of morphology 39, 257-268 (2001).[0233]4. Katoh, N., et al. Target-specific innervation by autonomic and sensory nerve fibers in hairy fetal skin transplanted into the anterior eye chamber of adult rat. Cell and tissue research 266, 259-263 (1991).[0234]5. Olson, L. & Seiger, A. Beating intraocular hearts: light-controlled rate by autonomic innervation from host iris. Journal of neurobiology 7, 193-203 (1976).[0235]6. Wu, W., Scott, D. E. & Reiter, R. J. Transplantation of the mammalian pineal gland: studies of surviv...

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Abstract

The present invention provides novel drug discovery platforms and methods for treating type I diabetes.

Description

CROSS REFERENCE[0001]This application claims priority to U.S. Provisional Patent Application Ser. Nos. 60 / 969,437 filed Aug. 31, 2007, 61 / 042,482 filed Apr. 4, 2008, and 60 / 989,038 filed Nov. 19, 2007, all incorporated by reference herein in their entirety.STATEMENT OF GOVERNMENT SUPPORT[0002]The work disclosed herein was supported in part by National Institute of Health Grant Numbers DK-58508 and DK-075487 and thus the U.S. government has certain rights in the invention.BACKGROUND OF THE INVENTION[0003]Fundamental understanding of cellular processes in health and disease has been gained by studying cells of various tissues in vitro. However, results obtained from experiments in vitro are often not sufficient to explain the performance of cells in more physiological settings like whole organs or living organisms. To place observations made in an in vitro system into a physiological context, studies have to be performed under in vivo conditions. In recent years an increasing number o...

Claims

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Application Information

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IPC IPC(8): A61K49/00A61K35/12A61P7/12A61K35/39
CPCA01K67/0271A01K2217/05A01K2227/105C12N2830/008A61K35/39A61K49/0008A01K2267/0325A61P3/10A61P5/50A61P7/12A61P31/00C12N5/0676
Inventor BERGGREN, PER-OLOFCAICEDO, ALEJANDRO
Owner BIOCRINE
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