Super-sparger microcarrier beads and precision extrusion deposited poly-epsilon-caprolactone structures for biological applications

Abstract

In on aspect, the invention includes a microcarrier bead having a porous three-dimensional core having (a) a polymeric porous three-dimensional body having porosity of about 15 to about 90% such that at least 99% of pores are interconnected and have diameters of at most 200 microns, (b) an outer protective layer and optionally (c) a filler. In another aspect, the invention includes a method of making an artificial scaffold wherein a scaffolding material is extruded into a coolant and thereby creating a porous material having a porosity of between 15-90% such that at least 99% of pores are interconnected and have diameters of at most 200 microns.

Description

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AI Technical Summary

Benefits of technology

This patent describes a type of small carrier bead made up of a hollow structure with tiny holes connected throughout it. These holes make up most of the volume of the bead and can hold other molecules or particles. There is also a thin layer of protection around the outside of this structure.

Problems solved by technology

This patent describes the technical problem of developing better ways to make microcarrier beads and scaffolds for growing animal cells and tissues in large amounts. Current methods involve limitations in terms of achieving high levels of cell growth and increasing production efficiency. There is also a need for improved tools to control pore size and interconnection within the structure of the scaffold.

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