Animal feed composition

a technology of animal feed and composition, applied in the field of animal feed composition, can solve the problems of preventing universal acceptance of non-human animals, limited supply of conventional food protein, and increasing the production of animal protein that does not seem to be proportional to the increase in world population, etc., and achieve the effect of enhancing the growth of non-human animals

Inactive Publication Date: 2007-08-09
VEIJLEN
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0007] It has now been found that the disadvantages of the prior art substances and methods can be overcome, and that the growth of non-human animals can be enhanced by orally administering free indole acetic acid (free IAA) or a derivative thereof to animals in conjunction with their normal feed or drinking water.

Problems solved by technology

Limited supply of conventional food protein is a major problem facing a rapid increase in world population.
Due to limited production facilities and lack of improvement in production technology, increase in animal protein production does not seem to proportionate the increase in world population.
The administration of each of these classes of substances had disadvantages, however, which have prevented their universal acceptance.
Thus, it is believed that antibiotics and surfactants, while effective under certain conditions, principally act to suppress diseases and do not elicit a true growth response.
It is for that reason that such use of antibiotics will be limited in Europe, whereas it is under debate in the USA and Asia.
Also, the use of estrogens as growth-promoting agents presents certain inherent difficulties and hazards.
Thus, estrogens frequently downgrade the animal to which they are administered.
Another disadvantage is that some of the estrogenic material may remain in the edible portions of the animal and could presumably produce an adverse effect on an individual when consumed.
Further, the known substances have principally been administered by injection or implantation procedures, which are both costly and time-consuming and are ofyen disliked by consumers.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

Source of free IAA

[0056] Free IAA or a derivative thereof may be obtained from any commercial source. Alternatively, free IAA may be produced in a microbiological way.

[0057] To this end, Azospirillum brasilence Sp7 (ATCC) was obtained as an agar culture in a culture tube. LB medium was used to grow the strain overnight at 28° C. at 175 rpm. Glycerol was added to the culture up to 10%, mixed and divided over Nalgene creovials and frozen at −80° C. Stocks were stored at −80 ° C. in creovials.

[0058] To prepare a seed culture of A. brasilence, one stock (1.2 to 1.8 ml) was thawed and added to 1 liter of LB medium and grown for about 20 h at 28° C. and 175 rpm to an Optical Density (OD620 nm) of about 2.5.

[0059] A 10 litre fermentor was rinsed with water and the pH electrode was calibrated. Nine litre of LB medium was prepared and 1 g / l L-Tryptophan and 0.1 g / l free IAA was added. The medium was entered into the fermentor together with 2 ml of anti foam. The fermentor was sterilised ...

example 2

Growth Rate of Poor Growing Piglets can be Improved with Free IAA

[0062] The trial was done in a well managed farm with 1000 sows of the Dutch Land race. Although the farm is well run, the technical performance was not optimal. There were latent problems with mortality and with growth rates of the piglets. There were too many poor growing piglets, without a clear underlying technical or veterinary reason. There was no clear pathology to be seen on the farm.

[0063] Three groups of piglets were randomly selected at day 1 of the trial. The first (control) group consisted of normal well growing piglets. The B group consisted of 78 poor growers, these were treated with free IAA. The X group consisted of 52 poor growers that were not treated.

[0064] The B group received free IAA in the feed, starting on day 5 of the trial. The feed for the B group was prepared by first mixing free IAA with dextrose which was then mixed with the feed. For that purpose, 4 gram of pure free IAA (Aldrich) was...

example 3

Growth of Healthy Laying Hens can be Improved with Free IAA

[0072] In this example normally growing animals were treated with free IAA. Growing laying hens of 10 weeks old were selected in the flock to create two groups of ten hens: [0073] Group GB: 10 normally growing hens, not treated [0074] Group GNA: 10 normally growing hens, treated with free IAA

[0075] The treated birds were force fed daily with a capsule with 400 ug free IAA / kg LW / DAY which corresponds to 10 mg / kg LW / DAY of a 4% mixture of free IAA in dextrose. Treatment was continued until the hens started laying. The two groups were weighed every week.

[0076] From the first week on, an improved weight gain was seen in the treated group when compared with the non-treated group. The improvement in weight gain was consistent over the first four weeks of the trial. The group GNA was about 2 weeks in advance of the normal rearing schedule.

[0077] The last couple of weeks of the experiment were very stressful for the birds, since...

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Abstract

The present invention relates to an animal feed composition that comprises free indole acetic acid (free IAA) or a derivative thereof. The invention also relates to a method for enhancing animal growth by feeding the animal with a composition according to the invention. The invention also relates to the use of free IAA or a derivative thereof in a method of therapy of animals in need of a growth-promoting treatment, such as immunocompromised animals, animals with a growth deficit or slow growing animals. The invention also relates to the use of free IAA or a derivative thereof for the preparation of a therapeutical composition for increasing the growth rate and / or the feed conversion rate and / or the immunity of animals in need of such a treatment, in particular immunocompromised or slow growing animals. A composition according to the invention may preferably be in the form of a food or feed supplement.

Description

FIELD OF THE INVENTION [0001] The present invention relates to an animal feed composition that comprises free indole acetic acid (free IAA) or a derivative thereof. The invention also relates to a method for enhancing animal growth by feeding the animal with a composition according to the invention. The invention also relates to the use of free IAA or a derivative thereof in a method of therapy of animals in need of a growth-promoting treatment, such as immunocompromised animals, animals with a growth deficit or slow growing animals. The invention also relates to the use of free IAA or a derivative thereof for the preparation of a therapeutical composition for increasing the growth rate and / or the feed conversion rate and / or the immunity of animals in need of such a treatment, in particular immunocompromised or slow growing animals. A composition according to the invention may preferably be in the form of a food or feed supplement. BACKGROUND OF THE INVENTION [0002] Limited supply o...

Claims

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Application Information

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IPC IPC(8): A61K31/405A61K47/00A23K1/16A23K1/18A23L13/00A61K31/404A61K31/4045A61K31/7056A61P5/00A61P37/02C07D209/18
CPCA23K1/1625A23K1/165A23K1/1826A23K1/184A23K1/188A23K1/1893Y10S426/807A61K31/4045A61K31/405A61K31/7056C07D209/18Y10S426/805A61K31/404A23K20/132A23K50/75A23K50/30A23K50/80A23K50/60A61P1/14A61P37/00A61P37/02A61P37/04A61P43/00A61P5/00A23K20/184A23K20/168
Inventor GILLESSEN, HUBERT JEAN MARIE FRANCOISREBIERE, CHRISTIAN
Owner VEIJLEN
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