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Targeted liposomal drug delivery system

a liposomal and drug delivery technology, applied in the field of metal complexes, can solve the problems of unwanted pharmacological responses and adverse side effects, and achieve the effect of convenient formulation and better glucose homeostasis

Inactive Publication Date: 2007-05-10
LAU JOHN R +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Agents that are delivered in a conventional or non-specific manner often spread or are dispersed to non-designated areas and thus exhibit adverse side effects and unwanted pharmacological responses.

Method used

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  • Targeted liposomal drug delivery system
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Embodiment Construction

Definitions

[0027] As used herein, the term “lower” means the group it is describing contains from 1 to 6 carbon atoms;

[0028] the term “alkyl” refers to a straight or branched chain hydrocarbon containing no unsaturation, and one substitution site, e.g., methyl(—CH3), ethyl(—CH2CH3), isopropyl [—CH(CH3)2], 2-butyl, neopental [(CH3)CCH2—], n-hexyl, etc.;

[0029] the term “alkylene” refers to a lower branched or unbranched alkyl group having two substitution sites, e.g., methylene (—CH2—), ethylene (—CH2CH2—), isopropylene

etc.;

[0030] the term “aryl” refers to a cyclic carbon ring structure, with or without saturation, that has one substitution site which consists of a group, e.g., phenyl, m-methoxyphenyl, tolyl, sterol, etc., of the formula in Example #1 where Z is hydrogen, halogen, loweralkyl, loweralkoxy, CF3, CN, NO2, and NH2 and p is an integer of 1 to 4;

[0031] the term “arylloweralkyl” refers to an aryl group, as defined above, linked to a lower alkylene group, through on...

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Abstract

A metal targeting complex which associates with a charged liposomal structure is provided. The metal targeting complex provides the targetability of the liposomal construct to the desired receptor sites of a warm-blooded host for therapy or diagnostic use.

Description

[0001] This application claims priority from U.S. provisional application Ser. No. 60 / 085,969 filed on May 19, 1998, under 35 USC 119(e)(i).FIELD OF THE INVENTION [0002] This invention pertains to metal complexes, such as water insoluble chromium complexes, and to targeted liposomal drug delivery systems containing the complexes, particularly those useful for the delivery of an agent to the hepatocytes of the liver. BACKGROUND OF THE INVENTION [0003] Liposomes, also known as vesicles, are generally composed of phospholipids and other lipid components such as cholesterol. They can function as carriers whose essential structural feature is a bipolar lipid membrane which envelops an aqueous core volume in which pharmacological agents are solubilized and therefore encapsulated. Liposomal encapsulated drugs have shown promise in treating diseases and have performed as diagnostic tools for the early detection of cancer and other maladies. As a result, liposomes have shown potential as sit...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K38/28A61K9/127C07F11/00A61K31/28
CPCA61K9/1271A61K38/28A61P43/00
Inventor LAU, JOHN R.GEHO, W. BLAIRSNEDEKER, GEORGE H.
Owner LAU JOHN R
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