Methods and composition for treatment of migraine and symptoms thereof

Abstract

Compositions, methods and kits are provided for the treatment of migraines. The compositions, methods and kits include an effective dose of trimethobenzamide and an ethanolamine antihistamine that, when administered to an individual suffering from migraine headaches, will alleviate symptoms associated with the migraine headaches. Compositions, methods, and kits for the treatment of migraines include pharmaceutical compositions of trimethobenzamide and diphenhydramine.

Description

CROSS-REFERENCE TO RELATED APPLICATIONS [0001] Not applicable. STATEMENT REGARDING FEDERALLY SPONSORED RESEARCH OR DEVELOPMENT [0002] Not applicable. REFERENCE TO A COMPACT DISK APPENDIX [0003] Not applicable. TECHNICAL FIELD [0004] This invention relates to compositions for the treatment of migraines, and also relates to methods for treatment of migraines. This invention also relates to the compositions and methods for the treatment of symptoms associated with migraines, including headache, nausea, dizziness, etc. BACKGROUND OF THE INVENTION [0005] Approximately 28 million Americans are estimated to suffer from migraine attacks, the majority of them women (20 million; Lipton et al. 2001 Headache 41(7): 646-657), making this one of the most prevalent disorders today, yet it has been reported that only a minority of sufferers are diagnosed and receive appropriate treatment (Silberstein et al., 2002 “Monograph: The State of Migraine: Prevention and Treatment” ACCESS Medical Group, Dep...

AI Technical Summary

Problems solved by technology

While it is apparent that migraine and the disability associated with severe migraine symptoms are a public health problem, the exact causes and mechanisms are still widely debated, which hampers treatment and diagnosis of the disorder.

However, to date, there does not appear to be a single treatment (including prevention or prophylaxis) that is successful for the majority of migraine sufferers.

Additionally, treatment that has proven effective in a particular migraine sufferer may not continue to be successful, or may only be intermitently effective.

Treatment during migraine is often either ineffective, only partially effective or the therapeutica agents are associated with significant undesirable side effects, including one or more of: hypotension, tiredness, increased weight, breathlessness, dizziness, heaviness or pressure on the chest and arms, shortness of breath, chest pain, nausea, muscle cramps, or peripheral vasoconstriction; depending on the therapy of choice.

As described above and known to those of skill in the art, a number of different therapies are available which may prevent or alleviate migraine some of the time for some individuals, but complete avoidance of the disease seems to be impossible and most of the prescribed drugs are known for their undesired side-effects.

However, beta-blockers have multiple side effects, like hypotension, tiredness, increased weight and breathlessness.

However, they have low oral and rectal bioavailablity and may cause nausea, muscle cramps, or peripheral vasoconstriction.

To date, there does not appear to be a drug or regimen which can effectively treat a broad range of those suffering from the pain and unpredictability associated with migraine.

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