Microneedle devices and methods of manufacture

Abstract

Microneedle devices and methods of manufacturing the microneedle devices. The microneedle devices include microneedles protruding from a substrate, with the microneedles piercing a cover placed over the substrate surface from which the microneedles protrude. The cover and the microneedle substrate together define a capillary volume in fluid communication with the base of each microneedle. One manner of using microneedle arrays of the present invention is in methods involving the penetration of skin to deliver medicaments or other substances and / or extract blood or tissue. Manufacturing methods may include simultaneous application of pressure and ultrasonic energy when piercing the cover with the microneedles.

Description

CROSS REFERENCE TO RELATED APPLICATIONS [0001] This application is a divisional of U.S. Ser. No. 10 / 051,745, filed Jan. 15, 2002, now pending, the disclosure of which is herein incorporated by reference.FIELD OF INVENTION [0002] The present invention relates to the field of microneedle devices and methods of manufacturing the same. BACKGROUND [0003] Arrays of relatively small structures, sometimes referred to as microneedles or micro-pins, have been disclosed for use in connection with the delivery and / or removal of therapeutic agents and other substances through the skin and other surfaces. [0004] The vast majority of known microneedle devices include structures having a capillary or passageway formed through the needle. Because the needles are themselves small, the passageways formed in the needles must be limited in size. As a result, the passageways can be difficult to manufacture because of their small size and the need for accurate location of the passageways within the needle...

AI Technical Summary

Benefits of technology

[0007] The capillary volume enhances the movement of fluid towards or away from the microneedles by wicking fluids towards or away from the microneedles. The wicking action may be accomplished by selection of suitable spacing between the substrate and the cover and / or by the selection of materials used for the various components in the devices. In some instances, coatings may be provided within the capillary volume, e.g., hydrophilic coatings, that may enhance the capillary wicking action within the capillary volume.

Problems solved by technology

Because the needles are themselves small, the passageways formed in the needles must be limited in size.

As a result, the passageways can be difficult to manufacture because of their small size and the need for accurate location of the passageways within the needles.

Another potential problem of passageways small enough to fit within the microneedles is that the passageways may become easily obstructed or clogged during use.

Images