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Method for preparing hydroxyapatite composite and biocompatible material

a technology of hydroxyapatite and biocompatible materials, which is applied in the field of preparing hydroxyapatite composites and biocompatible materials, can solve the problems of insufficient bonding strength of the obtained hap to the polymer matrix, slow growth speed of hap, and insufficient amount of hap on the polymer matrix, etc., and achieves rapid and efficient formation of hap, excellent bonding strength, and superior affinitiy

Inactive Publication Date: 2002-09-12
NOF CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Benefits of technology

[0009] It is an object of the present invention to provide a method for preparing a HAp composite having the composition and crystal structure similar to those of natural bone, and expected to have superior affinitiy, which method enables extremely rapid and efficient formation of HAp on a polymer or metal matrix with excellent bonding strength therebetween.
[0010] It is another object of the present invention to provide a biocompatible material that has HAp having the composition and structure similar to those of natural bone, that is expected to have superior affinity, and that has excellent bonding strength between the HAp and the matrix.
[0011] According to the present invention, there is provided a method for preparing a hydroxyapatite composite comprising alternately soaking a matrix which has been made hydrophilic at least on its surface (sometimes referred to as matrix (C) hereinbelow), in a calcium ion aqueous solution containing calcium ions and substantially free of phosphate ions (sometimes referred to as calcium ion aqueous solution (A) hereinbelow) and in a phosphate ion aqueous solution containing phosphate ions and substantially free of calcium ions (sometimes referred to as phosphate ion aqueous solution (B) hereinbelow) to securely form hydroxyapatite at least on the surface of the said matrix.

Problems solved by technology

In the biomimetic process, however, the growth speed of HAp is so slow that even the reaction for as long as more than two weeks cannot generate sufficient amount of HAp on the polymer matrix for use as artificial bone.
In addition, the bonding strength of the obtained HAp to the polymer matrix is sometimes insufficient.
In the alternate soaking process using a general-purpose polymer matrix, the step (b) may be achieved relatively easily, but it is difficult to proceed with the process beyond this step.

Method used

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  • Method for preparing hydroxyapatite composite and biocompatible material
  • Method for preparing hydroxyapatite composite and biocompatible material
  • Method for preparing hydroxyapatite composite and biocompatible material

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0048] Three pieces of 5.times.6 cm PE film manufactured by SHOWA DENKO K. K. were subjected to corona treatment at 15 kV for 2 minutes, 5 minutes, and 10 minutes, respectively, to obtain three kinds of PE film matrices that had been made hydrophilic on their surface. Each matrix was soaked in 10 ml of a 200 mM CaCl.sub.2 / Tris-HCl solution (pH 7.4, temperature at 37.degree. C.) for one minute, washed with pure water on its surface, soaked in acetone, and air-dried. A series of these operations including the soaking of the matrix in the calcium ion aqueous solution is referred to as soaking operation (i). Subsequently, each matrix was soaked in 10 ml of a 120 mM Na.sub.2HPO.sub.4 solution (temperature at 37.degree. C.) for one minute, washed with pure water on its surface, soaked in acetone, and air-dried. A series of these operations including the soaking of the matrix in the phosphate ion aqueous solution is referred to as soaking operation (ii).

[0049] A cycle of the alternate soak...

example 2

[0050] HAp was formed in the same way as in Example 1 except that the corona-treated PE film matrix was replaced with a PE film matrix that had been made hydrophilic on its surface by soaking PE film in sulfuric acid for 10 minutes for acid treatment. The resulting HAp composite was subjected to the measurement of the HAp amount and the Exfoliation Test in the same way as in Comparative Example 1. The results are shown in Table 1.

example 3

[0051] HAp was formed in the same way as in Example 1 except that the corona-treated PE film matrix was replaced with a PE film matrix that had been made hydrophilic on its surface by rubbing PE film surface with a P400 file in two diagonal directions each for 50 times and in total of 100 times for surface-filing treatment. The resulting HAp composite was subjected to the measurement of the HAp amount and the Exfoliation Test in the same way as in Comparative Example 1. The results are shown in Table 1.

1 TABLE 1 Treatment of Amount of HAp HAp Exfoliation matrix surface formed Test Comp. Ex. 1 None 2 .mu.g / cm.sup.2 Peeled Example 1 Corona treatment 3.9 .mu.g / cm.sup.2 Not Peeled for 2 min. Corona treatment 4.2 .mu.g / cm.sup.2 Not Peeled for 5 min. Corona treatment 5.1 .mu.g / cm.sup.2 Not Peeled for 10 min. Example 2 Acid (Sulfuric 2.7 .mu.g / cm.sup.2 Not Peeled acid) treatment Example 3 Filing 2.6 .mu.g / cm.sup.2 Not Peeled

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Abstract

A method for preparing a hydroxyapatite composite is disclosed. This method comprises alternately soaking a matrix which has been made hydrophilic at least on its surface, in a calcium ion aqueous solution containing calcium ions and substantially free of phosphate ions and in a phosphate ion aqueous solution containing phosphate ions and substantially free of calcium ions to securely form hydroxyapatite at least on the surface of the matrix. Also disclosed is a biocompatible material composed of the hydroxyapatite composite obtained by the method.

Description

FIELD OF THE INVENTION[0001] The present invention relates to a method for preparing a hydroxyapatite composite that has a composition similar to that of bone, and that is useful as various kinds of artificial tissues for living organisms such as artificial bone, as well as medical materials. The present invention also relates to a biocompatible material utilizing the composite obtained by the above method.DESCRIPTION OF RELATED ART[0002] Natural bone and teeth are molecular composites of inorganic hydroxyapatite (HAp) and collagen, arranged in a three-dimensional matrix. For repairing damaged bone and teeth, it is known to use biocompatible ceramics. Examples of such ceramics include "Bioglass" (trade name, manufactured by NIPPON ELECTRIC GLASS CO., LTD., OTSU. SIGA, JAPAN) composed of Na.sub.2O--CaO--SiO.sub.2--P.sub.2O.sub.5 and mainly used as a restorative materials in dental surgery, sintered HAp (Ca.sub.10(PO.sub.4).sub.6(OH).sub.2) mainly used as a bone filling material, and ...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/00A61L27/46
CPCA61K9/0024A61L27/46
Inventor AKASHITAGUCHI, TETSUSHIKISHIDA, AKIOHAYASHI, AKIO
Owner NOF CORP
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