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Antibacterial composition for topical administration containing antibiotic

an antibacterial composition and topical administration technology, which is applied in the direction of antiseptics, biocide, drug compositions, etc., can solve the problems of deterioration of active components, difficulty in achieving overall homogeneity, and no technique for using penem compounds as ointments

Inactive Publication Date: 2002-03-21
DAIICHI SUNTORY PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, penem compounds, like other .beta.-lactam compounds, are generally chemically labile to hydrolysis, oxidation, photoisomerization, etc., and no composition for topical administration has been known that exhibits their excellent efficacy against inflammatory or pyogenic diseases, or diseases caused by infection with resistant bacteria.
When an active component is in the form of crystals or a crystalline powder like penem antibiotics, it is difficult to achieve overall homogeneity simply by dispersing the component in a base.
However, no technique for use of a penem compound as a component of an ointment has hitherto been known.
Such external factors include, for example, high temperatures, light and oxygen, which would all cause a deterioration in the active component.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

example 1

[0038]

1 Component % by weight Compound 1 2.5.sup.1) Hydrocarbon gel.sup.2) 97.5 .sup.1)2.0% as free anhydride (the same applies below) .sup.2)Plastibase, available from Bristol-Myers Squibb Co. (the same applies below).

[0039] Compound 1 was mixed with hydrocarbon gel to overall homogeneity to give the desired composition.

example 2

[0040]

2 Component % by weight Compound 1 6.2.sup.3) Hydrocarbon gel.sup.2) 93.8 .sup.3)5.0% as free anydride.

[0041] Compound 1 was mixed with hydrocarbon gel to overall homogeneity to give the desired composition.

example 3

[0042]

3 Component % by weight Compound 1 12.4.sup.4) Hydrocarbon gel 87.6 .sup.4)10.0% as free anydride.

[0043] Compound 1 was mixed with hydrocarbon gel to overall homogeneity to give the desired composition.

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PUM

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Abstract

The present invention provides a safe antibacterial composition for topical administration which stably contains a penem antibiotic having a broad-spectrum and potent antibacterial activity while otherwise being chemically susceptible to hydrolysis, oxidation, photoisomerization or the like. The compositions of the present invention comprise an antibacterial composition for topical administration comprising a penem antibiotic or a pharmaceutically acceptable salt thereof in a non-aqueous base.

Description

[0001] The present invention relates to pharmaceutical compositions for use in dermatological, ophthalmologic, otolaryngologic, dental / oral surgical and urogenital fields, and more specifically to the use of penem antibiotics for topical administration.PRIOR ART[0002] Ointments are used for topical administration to treat various diseases due to their convenience of administration and portability.[0003] Therapeutic agents comprising antibiotics in an ointment base are useful for treating local inflammatory or pyogenic diseases caused by bacterial infection. There is a demand for these ointments, with a number being available.[0004] For example, ointments containing aminoglycoside, tetracycline and chloramphenicol antibiotics are commonly used for inflammatory or pyogenic diseases in dermatological, ophthalmologic, otolaryngologic, dental / oral surgical and urogenital fields. Specific examples include commercially available dermatological agents for pyogenic diseases, based on aminogl...

Claims

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Application Information

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Patent Type & Authority Applications(United States)
IPC IPC(8): A61K9/00A61K31/43A61K47/06A61K47/32A61K47/36C07D499/88
CPCA61K9/0014A61K9/0063A61K31/43A61K47/06A61K47/32A61K47/36C07D499/88A61P31/00A61P31/02A61K47/30
Inventor NOMURA, MASAAKISUMIKAWA, HIROMISUGITA, OSAMU
Owner DAIICHI SUNTORY PHARMA CO LTD
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