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Use of brown algae polyose sulfate in preparing medicine fortreating cardic and cerebral vascular diseases

A technology of cardiovascular and cerebrovascular diseases and fucoidan, which is applied in the field of the use of fucoidan sulfate in the preparation of drugs for the treatment of cardiovascular and cerebrovascular diseases, and can solve the problems such as fucoidan sulfate that have not been shown in the literature

Inactive Publication Date: 2007-06-27
BEIJING CENTURY BIOCOM PHARMA TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no literature showing the use of fucoidan sulfate in the treatment of coronary heart disease, stroke and other diseases

Method used

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  • Use of brown algae polyose sulfate in preparing medicine fortreating cardic and cerebral vascular diseases
  • Use of brown algae polyose sulfate in preparing medicine fortreating cardic and cerebral vascular diseases
  • Use of brown algae polyose sulfate in preparing medicine fortreating cardic and cerebral vascular diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Example 1 Preparation of Fucoidan Sulfate

[0032] After crushing seaweed, soak it in 3.7% formaldehyde solution overnight, then add distilled water and boil it for extraction, and filter the extract with diatomaceous earth, dialyze the filtrate with running water for one day, then dialyze with distilled water for one day, concentrate the dialysate, add ethanol to The concentration is 75% precipitation, and the precipitation is dried to obtain crude fucoidan sulfate ester. Redissolve the crude product in water at 0.05mol / L MgCl 2 Precipitate with 20% ethanol to remove water-soluble alginate, dialyze the filtrate, concentrate, precipitate with 75% ethanol, and obtain purified fucoidan sulfate after drying. The molecular weight is determined by high performance gel permeation chromatography. Prepare four kinds of seaweed fucoidan sulfate esters according to the above method, and its chemical composition analysis is shown in the following table:

[0033]

...

Embodiment 2

[0037] The preparation of embodiment 2 fucoidan sulfate injection

[0038] Take kelp fucoidan sulfate 50g, add water for injection 500ml, mannitol 50g, adjust the pH value to 7.0, subpackage, and freeze-dry.

Embodiment 3

[0039] The preparation of embodiment 3 fucoidan sulfate ester tablet

[0040] Take kelp fucoidan sulfate 50g, add microcrystalline cellulose, polyvinylpyrrolidone, mix, add appropriate amount of water, make soft material, granulate, and dry. The granules are added with croscarmellose sodium and magnesium stearate, mixed, and pressed into tablets. Each tablet contains 100 mg of fucoidan sulfate.

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PUM

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Abstract

The present invention discloses the use of brown algae polyose sulfate in preparing medicine for treating cardiac and cerebral vascular diseases, including asymptomatic coronary heart disease, angina type coronary heart disease, myocardial infarction, arrhythmia, sudden death type coronary heart disease, etc. The brown algae polyose sulfate may be extracted from kelp and has molecular weight of 10KD-1000KD.

Description

technical field [0001] The invention relates to the pharmaceutical use of fucoidan sulfate, in particular to the use of fucoidan sulfate in the preparation of drugs for treating cardiovascular and cerebrovascular diseases. Background technique [0002] Fucoidan sulfate is a class of sulfated polysaccharides that exist in brown algae and was first extracted from kelp palmate by Kylin in 1913 with dilute acid. Kylin separated the L-fucose after hydrolyzing the extract. He named this polysaccharide fucoidin. Now it is generally named fucoidan according to the naming principle of polysaccharides. The Chinese name is fucoidan, fucoidan, and fucoidan. , fucoidan sulfate, fucoidan or fucoidan sulfate. Now people have a relatively clear understanding of the composition of fucoidan sulfate esters. It is a type of polysaccharide with very complex chemical composition and structure. It is mainly composed of fucose and sulfate groups. Sugar, uronic acid and other ingredients. Kelp Fu...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/737A61P9/10
CPCA61K36/03A61K9/2054A61K9/2027A61K9/0019A61K31/737A61P7/02A61P7/04A61P9/00A61P9/06A61P9/10
Inventor 郝守祝李静
Owner BEIJING CENTURY BIOCOM PHARMA TECH
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