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Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain

An immunomodulatory, compound technology used in the prevention, improvement and control of pain, therapeutic areas

Inactive Publication Date: 2007-01-17
CELGENE CORP
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, few patients experience complete healing of their pain

Method used

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  • Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
  • Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain
  • Methods of using and compositions comprising immunomodulatory compounds for treatment, modification and management of pain

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Embodiment Construction

[0041] The present invention is partly based on the idea that the compounds disclosed in the present invention can act alone or in combination with other drugs to effectively treat, prevent, improve and / or control various types and severity of pain. Without being bound by theory, the compounds of the invention may, but need not be, act as analgesics. Specifically, because certain compounds can surprisingly affect the production of cytokines (e.g., TNF-α, IL-1β, IL12, and IL-4), it is thought that they may be effective by reducing the baseline Or restore the normal pain domain and have the function of "anti-hyperalgesia" and / or "neuromodulator". Thus, the compounds of the present invention may exert different effects from analgesics, which generally only reduce stimulus-induced responses, whereas the compounds of the present invention may act by inhibiting pain-related distress or directly reducing the reactivity of nociceptors. Alter the patient's ability to tolerate this res...

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Abstract

Methods of treating, preventing, modifying and managing various types of pain are disclosed. Specific methods comprise the administration of a selective cytokine inhibitory drug, or a pharmaceutically acceptable salt, solvate, hydrate, stereoisomer, clathrate, or prodrug thereof, alone or in combination with a second active agent and / or surgery, psychological or physical therapy. Pharmaceutical compositions, single unit dosage forms, and kits suitable for use in methods of the invention are also disclosed.

Description

1. Field of invention [0001] The present invention relates to methods for the treatment, prevention, amelioration and control of pain comprising administering an immunomodulatory compound alone or in combination with known therapies. The invention also relates to pharmaceutical compositions and dosage regimens. In particular, the invention encompasses the use of immunomodulatory compounds in combination with other standard treatments for nerve blockade and / or pain symptoms. 2. Background of the invention [0002] Pain is the first symptom of many different diseases and is defined as an unpleasant sensory and emotional experience associated with or described in terms of actual or potential tissue damage. Merskey H, Bogduk N, eds., Classification of Chronic Pain, International Association for the Study of Pain (IASP) Classification Special Section, IASP Press: Seattle, 209-214, 1994. Because the perception of pain is highly subjective, it is one of the most difficult conditi...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/445A61K31/415A01N43/38A01N43/42A01N43/90A61KA61K31/40A61K31/44A61K31/454A61K31/47A61K31/52
CPCA61K31/60A61K31/4035A61K45/06A61P17/02A61P19/02A61P19/04A61P19/08A61P21/00A61P25/00A61P25/02A61P25/04A61P29/00A61P37/02A61P43/00A61P3/10A61K2300/00A61K31/445A61K31/519A61K31/47
Inventor 杰罗米·B·杰奥迪斯赫伯特·费莱克唐纳德·C·曼宁
Owner CELGENE CORP
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