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Bone cement compositions having fiber-reinforcement and/or increased flowability

A composition, fiber technology, applied in surgical adhesives, medical science, prosthesis, etc., can solve problems that are rarely raised, etc.

Active Publication Date: 2006-12-06
辛西斯有限责任公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is little prior art proposing implantable materials comprising resorbable or biodegradable fibers within a ceramic matrix

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0174] Example 1: Implantable composition comprising resorbable fibers according to the invention

[0175] Specific fiber reinforced compositions are listed in Table 2 below.

[0176] Examples#

Calcium Phosphate Composition

resorbable fiber

1D

Comparative Example 1A

1% (3mm×16-20μm) L6 fiber

1E

Comparative Example 1A

2% (3mm×16-20μm) L6 fiber

1F

Comparative Example 1A

2% (6mm×16-20μm) L6 fiber

1G

Comparative Example 1A

1% (8mm×16-20μm) L6 fiber

1H

Comparative Example 1A

2% (8mm×16-20μm) L6 fiber

1J

Comparative Example 1A

2% (8mm×16-20μm) L6 dog bone fiber

1K

Comparative Example 1A

1% (3mm×16-20μm) LACTOMER fiber

1L

Comparative Example 1A

2% (3mm×16-20μm) LACTOMER fiber

1M

Comparative Example 1A

2% (3mm long) LACTOMER 9-1 fiber

[0177] L6 fibers are short copolymer fibers of 82% glycolide and 18% lactide...

Embodiment 2

[0179] Example 2: Implantable composition comprising continuous reinforcing fibers according to the invention

[0180] Table 3 below lists specific continuous fiber or web reinforced compositions.

[0181] Examples#

Calcium Phosphate Composition

continuous fiber or web

2A

Comparative Example 1A

LACTOMER cable network

2B

Comparative Example 1A

cotton cheesecloth

[0182] LACTOMER cable nets comprise twisted and braided glycolide-L-lactide copolymer fibers and are commercially available from U.S. Surgical of New Haven CT.

[0183] By grinding the solid components of the bone cement of Comparative Example 1A with a mortar and pestle, adding the liquid components of the bone cement of Comparative Example 1A, the resulting slurry was formed into a standard shape (for subsequent ), placing continuous reinforcing fibers or a web around the exterior of the forming slurry, applying light pressure to embed the continuous reinfor...

Embodiment 3

[0184] Example 3: Implantable composition comprising a flow additive according to the invention

[0185] Table 4 below lists specific flowable / injectable compositions.

[0186] Examples#

Calcium Phosphate Composition

flow additive 1

Na 2 HPO 4 the solution

3A

Comparative Example 1A

0.3wt% sodium hyaluronate

0.15m, L / S=0.48

3B

Comparative Example 1B

0.3wt% sodium hyaluronate

0.075m, L / S=0.42

3C

Comparative Example 1B

0.6wt% sodium hyaluronate

0.075m, L / S=0.42

3D

Comparative Example 1B

0.6wt% sodium hyaluronate

0.075m, L / S=0.52

3E

Comparative Example 1B

1.4wt% sodium hyaluronate

0.075m, L / S=0.42

[0187] 1 Based on excluding Na 2 HPO 4 weight of the solution.

[0188] By grinding the solid components of the bone cement of Comparative Example 1A or 1B with a mortar and pestle, adding the sodium hyaluronate-sodium phosphate solution and the ...

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Abstract

The present invention relates in general to implantable compositions, and method for preparing same, containing a calcium salt-containing component, optionally demineralized bone, a plurality of discrete fibers, optionally a flow additive, and optionally continuous reinforcing fibers or an array of organized fibers in the form of mesh. Advantageously, the discrete fibers have a specific aspect ratio (length / diameter) from about 50:1 to about 1000:1. The addition of a small amount of discrete fibers and / or the continuous reinforcing fibers or fiber mesh can cause drastic increases in certain mechanical properties including flexural strength, flexural strength, flexural toughness, and / or screw pullout strength.

Description

[0001] This application claims the benefit of U.S. Provisional Application No. 60 / 500,346, filed September 5, 2003, and U.S. Provisional Application No. 60 / 574,532, filed May 25, 2004, the entire disclosures of each of which are incorporated herein in their entirety Reference. field of invention [0002] The present invention generally relates to implantable compositions comprising a calcium salt-containing component, a plurality of discrete fibers, optionally demineralized bone, an optional flow additive and any Choose continuous reinforcing fibers or arrays of organized fibers in the form of mesh. Advantageously, the discontinuous fibers have a specific aspect ratio (length / diameter) of from about 50:1 to about 1000:1. The addition of small amounts of discontinuous fibers and / or continuous reinforcing fibers or webs can lead to dramatic increases in certain mechanical properties including flexural strength, flexural toughness, and / or screw pullout strength. Background of ...

Claims

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Application Information

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IPC IPC(8): A61L27/46A61L27/50A61L24/00A61L27/42
Inventor 布赖恩·M·阿米蒂奇艾拉·艾森肖恩·克尔马克·富尔默迈克尔·莱米克威廉·希弗帕特里克·利米
Owner 辛西斯有限责任公司
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