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Duct filler material in use for bridge grafting nerves, and preparation method

A filling material and bridging technology, which is used in medical science, prosthesis, surgery, etc., can solve the problems that have not been seen in retrieval, and achieve the effect of preventing the collapse of the tube wall, improving the curative effect, and applying simple operation.

Inactive Publication Date: 2006-12-06
锦州医学院附属第一医院 +1
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AI Technical Summary

Problems solved by technology

Sodium hyaluronate as the main component of the catheter filling material for nerve bridging has not been found in the current search

Method used

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Examples

Experimental program
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Embodiment Construction

[0044] 1. (1) Add sodium hyaluronate dry powder into deionized water to form a 0.1% sodium hyaluronate solution, filter through a 0.22 μm cellulose acetate membrane, collect the sterile filtrate, and add 4 times the amount of Bacillus acetone solution, collect precipitate, obtain sterile sodium hyaluronate refined dry powder (A) after vacuum-drying;

[0045] (2) Get 6mg sodium hyaluronate refined dry powder (A), dissolve in 1ml physiological balance solution (B) [77% DMEM (GIBCO company), 20% FBS (SIGMA company)], 2% Glutamine (SIGMA company) and 1% penicillin streptomycin (Dalian Merro), adjust the pH value to 7.0-7.4 with sodium hydroxide solution, add an appropriate amount of (C) [nerve growth factor (20ng / μl)] to make the concentration reach 5%, stir well Formulated as sodium hyaluronate gel. Refrigerate at 1-10°C for later use.

[0046] Before the operation, the refrigerated sodium hyaluronate gel was taken out and placed at room temperature. During the operation, the e...

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PUM

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Abstract

A filler of the guide tube used for bridging nerve is a high-purity transparent gel prepared from sodium hyaluronate and the physiologically balanced liquid through purifying by filter method. The cells or factors for promoting the repair and growth of nerve are added to the gel.

Description

Technical field [0001] The invention belongs to a new type of tissue engineering filling material used for repairing and regenerating nerve defects, in particular to a filling material used in nerve bridge catheters as nerve growth-promoting cells and various factor carriers and a preparation method thereof. Background technique [0002] At present, most of the repair of nerve defects in clinical work still adopts the method of autologous nerve transplantation, and relatively minor nerves are used as donors to repair the defective nerves. In addition to the disadvantage of sacrificing the nerve function of the donor area, this method also has the serious disadvantage of being unable to effectively treat long-term nerve defects. With the rapid development of tissue engineering, the advent of catheter bridging has solved this long-term problem for clinicians to a certain extent. However, although various biomaterials such as veins, silicone tubes, and chitosan are used in the...

Claims

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Application Information

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IPC IPC(8): A61L27/40A61L27/38A61L31/00
Inventor 王伟范明徐艳孙亮刘淑红
Owner 锦州医学院附属第一医院
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