Vaginal adhesion preparation containing nano silver and its preparing process
A nano-silver and preparation technology, applied in the field of medicinal chemistry and pharmaceutical preparations, can solve problems such as affecting the adhesion of bioadhesive preparations
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Embodiment 1
[0041] Embodiment 1: prepare the vaginal adhesive preparation of nano silver
[0042] composition
[0043] Cetyl Alcohol 3%
[0044] Stearyl Alcohol 8.5%
[0045] Glyceryl Monostearate 2.5%
[0046] Propylene Glycol 10%
[0047] Tween 80 2%
[0048] Nano silver dispersion (2000ppm) 3%
[0049] Benzoic acid 0.1%
[0050] Sodium hydroxide to adjust pH to 4.0
[0051] water to 100%
[0052] Prepare vaginal adhesion cream according to the following preparation process:
[0053] Put cetyl alcohol, stearyl alcohol, glyceryl monostearate and Tween 80 in a suitable container and heat it to 80°C and keep it warm as the oil phase; the water phase consists of propylene glycol, benzoic acid and an appropriate amount of water In another container, add sodium hydroxide to adjust the pH value, heat to 80°C and keep it warm. Add the water phase into the oil phase under the condition of stirring, emulsify, continue to stir and cool to 40° C., and add the nano-silver solution. The cr...
Embodiment 2
[0054] Embodiment 2: prepare the vaginal adhesive preparation of nano silver
[0055] composition
[0056] Cetyl Alcohol 2%
[0057] Stearyl Alcohol 11%
[0058] Isopropyl Palmitate 4%
[0059] Propylene Glycol 5%
[0060] Tween 80 1.5%
[0061] Nano silver dispersion (2000ppm) 0.5%
[0062] Sorbic acid 0.1%
[0063] Potassium hydroxide to adjust pH to 4.0
[0064] water to 100%
[0065] Embodiment 2 is made cream by the preparation method under embodiment 1.
Embodiment 3
[0066] Embodiment 3: prepare the vaginal adhesive preparation of nano silver
[0067] composition
[0068] Cetyl Alcohol 5%
[0069] Stearyl Alcohol 15%
[0070] Isopropyl Myristate 2.5%
[0071] Propylene Glycol 10%
[0072] Tween 80 4%
[0073] Nano silver dispersion (2000ppm) 10%
[0074] Lactic acid 0.1%
[0075] Sodium hydroxide to adjust pH to 3.8
[0076] water to 100%
[0077] Embodiment 3 is made cream by the preparation method under embodiment 1.
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