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Gastrodin slow release preparation

A technology of sustained-release preparations and gastrodin, which is applied in the directions of medical preparations containing active ingredients, drug delivery, organic active ingredients, etc., can solve the problems of poor compliance, unstable blood drug concentration, and frequent taking of ordinary oral preparations, etc. Easy-to-dose results

Inactive Publication Date: 2006-08-30
魏锐 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The gastrodin preparations currently on the market are common oral preparations. Common oral preparations are often taken, the blood concentration is unstable, and the compliance is poor, and the indication cycle is long.

Method used

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  • Gastrodin slow release preparation
  • Gastrodin slow release preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] The preparation of embodiment 1 gastrodin sustained release coated tablet

[0033] prescription

[0034] Tablet prescription:

[0035] Ingredient Weight

[0036] Gastrodin 75mg

[0037] HPMC-75RT15000 54mg

[0038] HPMC-75RT4000 54mg

[0039] Microcrystalline Cellulose 84.3mg

[0040] 3% PVP in 75% ethanol solution 0.2ml

[0041] Magnesium Stearate 2.7mg

[0042] Coating prescription:

[0043] GS-N type coating powder 8.1mg

[0044] Preparation:

[0045] Chip process:

[0046] (1) Pulverization: take the raw and auxiliary materials of prescription quantity, pass through 80 mesh sieves respectively;

[0047](2) Granulation: mix gastrodin, hypromellose and microcrystalline cellulose, add 3% PVP in 75% ethanol solution as wetting agent to make soft material, pass through a 20-mesh sieve to granulate.

[0048] (3) Drying and sizing: dry the wet granules at 50-60°C, and sieve with 18 meshes.

[0049] (4) Tablet compression: add magnesium stearate to the dry gran...

Embodiment 2

[0055] The preparation of embodiment 2 gastrodin sustained-release tablets

[0056] Prescription: Ingredients Weight

[0057] Gastrodin 75mg

[0058] HPMC-75RT15000 54mg

[0059] HPMC-75RT4000 54mg

[0060] Microcrystalline Cellulose 84.3mg

[0061] 3% PVP in 75% ethanol solution 0.16ml

[0062] Magnesium Stearate 2.7mg

[0063] Preparation method: wet granulate gastrodin, hydroxypropyl methylcellulose, and microcrystalline cellulose, after granulation, add magnesium stearate and mix well, control the tablet weight, and press into tablets to obtain gastrodin sustained-release tablets .

Embodiment 3

[0064] The preparation of embodiment 3 gastrodin sustained-release tablets / capsules

[0065] Recipe: Ingredients Weight

[0066] Gastrodin 75mg

[0067] Sodium Alginate 66mg

[0068] Calcium Alginate 10mg

[0069] Lactose 40mg

[0070] Magnesium Stearate 2mg

[0071] Water (or ethanol aqueous solution) 0.3ml

[0072] Preparation method: fully mix gastrodin, sodium alginate, calcium alginate, and lactose, add appropriate amount of water (or ethanol aqueous solution) to make soft material, dry after granulation, granulate, add magnesium stearate and mix evenly, The weight of the tablet is controlled, and the tablet is obtained immediately. The granules can also be added into hollow capsules after granulation, drying and sizing to obtain gastrodin sustained-release capsules.

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PUM

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Abstract

A slow-releasing gastrodine and its preparing process are disclosed.

Description

technical field [0001] The invention relates to a pharmaceutical preparation and a preparation method thereof, more specifically, the invention discloses a gastrodin sustained-release preparation and a preparation method thereof. Background technique [0002] Due to the accelerated pace of work and life, there are more and more patients with neurasthenia, neurasthenia syndrome, angioneurotic headache, etc., which have reached 13%. However, there are currently no effective treatments and drugs for this type of disease. Work and life bring misery, although there are many kinds of medicines for neurasthenia, neurasthenia syndrome, and angioneurotic headache, there is no specific treatment medicine yet. Therefore, drugs that can improve symptoms and have little side effects are widely welcomed by patients. [0003] The chemical name of gastrodin is 4-hydroxyphenyl-β-D glucopyranoside, which is a neuropsychiatric drug. It is water-soluble and breaks down into gastrodin aglycone...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/22A61P25/20A61P25/04
Inventor 魏锐程琪
Owner 魏锐
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