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Anti-pruritic formulation containing capsaicin, and its preparing method and use

A technology of capsaicin and preparations, which is applied in the field of antipruritic preparations containing capsaicin, to achieve the effect of safe use, good detumescence effect and long acting time

Inactive Publication Date: 2006-08-09
BIOLOGY INST OF SHANDONG ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But for the itching that people often encounter in daily life due to mosquito bites, there are no related literature reports

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Example 1: Preparation of Capsaicin Antipruritic Lotion

[0017] Capsaicin, 20 g of menthol, and 200 ml of propylene glycol were dissolved and diluted into 1000 ml with 35% ethanol to obtain a solution with a concentration of capsaicin of 0.05%, a concentration of menthol of 2%, and 20% of propylene glycol.

Embodiment 2

[0018] Embodiment 2: antipruritic test

[0019] For 20 patients (12 males and 18 females) aged 9-62 years old, these patients were bitten by mosquitoes or fleas at two or more places. Rub the same amount of Capsaicin Antipruritic Lotion (A) and Fengyoujing (B, Guangzhou Baiyunshan Traditional Chinese Medicine Factory) of the present invention on two itching parts of the patient for self-comparison.

[0020] result

[0021] 1. Antipruritic effect (including antipruritic effect and swelling effect):

[0022] A is better than B in 67%; A is equal to B in 24%; B is better than A in 9%.

[0023] By chi-square test, A was significantly better than B (p<0.05).

[0024] 2. Effective time:

[0025] A is 2.3±0.7min; B is 4.8±0.8min.

[0026] After t test, A was significantly better than B (p<0.05).

[0027] 3. Duration of action:

[0028] A is 20.6±3.5min; B is 3.0±0.5min.

[0029] After t test, A was significantly better than B (p<0.05).

[0030] 4. Adverse reactions:

[0031...

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PUM

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Abstract

The present invention provides an itching-relieving preparation containing capsaicine and its preparation method. Said preparation method is characterized by dissolving capsaicine, menthanol and propanediol in 10-80% ethyl alcohol to make the concentration of capsaicine be 0.03-0.07%, concentration of menthanol be 1-5% and the concentration of propanediol be 15-35%. The invented itching-relieving preparation can be used for making medicine for curing itching and swelling pain due to mosquito bite.

Description

technical field [0001] The invention relates to an antipruritic medicine, in particular to an antipruritic preparation containing capsaicin. Background technique [0002] Skin itching and redness caused by mosquito bites often annoy patients. The bites affect the appearance of exposed skin and affect sleep at night. In severe cases, frequent scratching causes skin damage and ulceration. At present, there is no good treatment for the itching and redness caused by mosquito bites. Those with mild symptoms will not be treated basically, and those with severe symptoms will be treated with the following drugs: 1. Cool drugs. This type of medicine is a variety of medicines made of menthol as the base, which relieves itching through a cooling effect, such as cool oil and essential oils. This type of drug is the most widely used clinically, with menthol as the representative component. Menthol can stimulate the pain and cold receptors of the nerve endings of the local skin, and ca...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/165A61P17/04
Inventor 韩利文王希敏王雪侯海荣刘可春刘昌衡宋广运
Owner BIOLOGY INST OF SHANDONG ACAD OF SCI
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