Assistant for high-intensity focusing ultrasonic therapy and its screening method

A focused ultrasound, high-intensity technology, applied in the fields of medicine, medical treatment, and ultrasound therapy, it can solve the problems of decreased treatment efficiency, prolonged treatment time, burns, etc., and achieve the effects of improving damage effect, increasing energy deposition, and enhancing absorption characteristics.

Active Publication Date: 2006-07-19
CHONGQING HAIFU (HIFU) TECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, when HIFU technology is used to treat deep and large tumors, due to energy attenuation, the energy reaching the target area will be low, the treatment efficiency will decrease, and the treatment time will be prolonged.
[0004] Of course, in order to improve the treatment efficiency, although the transmission power of the ultrasonic transducer can be simply increased, the possibility of the normal tissue on the ultrasonic propagation channel being burned is greatly increased.
[0005] In addition, when HIFU technology is used clinically to treat liver tumors with ribs blocking the acoustic channel, in order to increase the energy deposition in the treatment target area, improve the treatment speed and treatment effect, it is often necessary to resect the ribs on the acoustic channel before treatment. This is contrary to the concept of HIFU non-invasive treatment, so it is difficult to be recognized by patients and doctors
[0006] The existence of these factors will inevitably affect and limit the promotion and popularization of HIFU as a clinically applicable technology to a certain extent.

Method used

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  • Assistant for high-intensity focusing ultrasonic therapy and its screening method
  • Assistant for high-intensity focusing ultrasonic therapy and its screening method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment I

[0035] The preparation of embodiment 1 HIFU therapy microparticles auxiliary agent

[0036] The encapsulated liquid of embodiment I-1 does not produce liquid / gas phase transition at 38~100°C

Embodiment I-1-1

[0038] Weigh respectively 4 g of iodized oil for injection (purchased from Shanghai Chemical Reagent Company), 0.6 g of egg yolk lecithin for injection (purchased from Shanghai Chemical Reagent Company), 1.25 g of glycerin for injection (purchased from Shanghai Chemical Reagent Company), mix and heat Dissolve it at 70° C. to form an oil phase, add distilled water containing 1% (W / V) emulsifier F-68 (purchased from Sigma) to the oil phase to 17.5 ml, form colostrum after vigorous shaking. Put the above-mentioned colostrum in a large test tube, ultrasonically emulsify the colostrum for 2 minutes at a power of 350W to form a uniform emulsified lipiodol, and then sterilize it by circulating steam at 100°C for 30 minutes. The pH value is 7.5-8.5 and contains iodine. Amount 0.13g / ml. Particle size <1μm, osmotic pressure 350mosm / kg water.

Embodiment I-1-2～ Embodiment I-1-4

[0040] According to the same method and steps described in Example I-1-1, use soybean oil for injection instead of iodized oil for injection as core material, use lecithin for injection instead of egg yolk lecithin as film-forming material, according to the following table 1 The listed ratios obtain the following particulate adjuvants for HIFU therapy of the present invention. The obtained adjuvant is a white milky liquid, which is suitable for intravenous injection of animals and humans, and the corresponding parameters are shown in Table 1 below:

[0041]

[0042] The wrapped liquid of embodiment I-2 produces liquid / gas phase transition at 38~100°C

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Abstract

The invention discloses an adjuvant for high-intensity focusing and ultrasonic (HIFU) treatment, which can be used for lowering the EEF of the HIFU therapeutic target region for the patients, the adjuvant makes it possible to carry out HIFU treatment during deep layer tumor treatment without the requirement of ablation of the patients' rib. The invention also provides a method for increasing target region energy deposition and screening HIFU adjuvant in HIFU treatment.

Description

technical field [0001] The present invention relates to the field of medicine and medical treatment, in particular, the present invention relates to the field of ultrasonic therapy, more specifically, the present invention relates to an auxiliary agent for HIFU treatment capable of increasing energy deposition in target tissue during HIFU treatment and a screening method thereof. Background technique [0002] High-intensity focused ultrasound (HIFU) technology has been clinically recognized as a new method for treating tumors and other diseases. It forms high-intensity and continuous ultrasonic energy on the lesion by focusing ultrasonic waves, thereby producing transient high-temperature effects (65-100°C), cavitation effects, mechanical effects, and sonochemical effects, and selectively causing coagulation necrosis of lesion tissues. The tumor loses the ability to proliferate, invade and metastasize. [0003] Studies have shown that during the propagation of ultrasound in...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K45/00A61K49/06A61K49/22
CPCA61K41/0052A61K41/0028A61P35/00A61K8/49
Inventor 王智彪李发琪肖雁冰肖子文刘丽萍王芷龙
Owner CHONGQING HAIFU (HIFU) TECHNOLOGY CO LTD
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