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Medicine composition and its preparation method and quality control method

A composition and drug technology, which can be used in drug combinations, testing drug preparations, pharmaceutical formulations, etc., and can solve problems such as large toxic and side effects

Inactive Publication Date: 2006-07-19
北京凯瑞创新医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, Western medicine mainly uses central nervous system stimulants to treat this disease. Commonly used drugs include methylphenidate, pemoline, etc., but the side effects are relatively large.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0071] [Prescription] Rehmannia glutinosa 500g, Chinese yam 225g, Poria cocos 150g, Moutan bark 150g

[0072] Alisma 150g Polygala 150g Keel 375g Ligustrum 225g

[0073] Phellodendron 150g Anemarrhena 75g Schisandra 75g Shichangpu 225g

[0074] Preparation method: 1. Take the above twelve flavors, take the keel and smash them into small pieces, add 10 times the amount of water, boil for 1 hour, then add eleven flavors such as yam, add water to decoct twice, add 8 times the amount of water for the first time , decoct for 2 hours, add 6 times the amount of water for the second time, decoct for 1.5 hours, combine the two decoctions, filter, and concentrate the filtrate under reduced pressure (65~75°C, -0.08MPa) to a relative density of 1.10~1.15 (60°C) clear paste.

[0075] 2. Take the clear paste obtained in 1, preheat to 80°C, mix in 100g of dextrin, spray dry (inlet air temperature 190±5°C, outlet air temperature 90±5°C), add 2g of aspartame to the spray dry powder, and Add...

Embodiment 2

[0077] [Prescription] Rehmannia glutinosa 500g, Chinese yam 225g, Poria cocos 150g, Moutan bark 150g

[0078] Alisma 150g Polygala 150g Keel 375g Ligustrum 225g

[0079] Phellodendron 150g Anemarrhena 75g Schisandra 75g Shichangpu 225g

[0080] [Method] Take the above twelve flavors, take the keel and smash them into small pieces, add 10 times the amount of water, boil for 1 hour, then add eleven flavors such as yam, add water to decoct twice, add 8 times the amount of water for the first time, Decoct for 2 hours, add 6 times the amount of water for the second time, decoct for 1.5 hours, combine the two decoctions, filter, and concentrate the filtrate under reduced pressure to a clear paste with a relative density of 1.10-1.15 (60°C), mix in an appropriate amount of paste The essence is spray-dried, the spray-dried powder is added with aspartame, and the total amount is adjusted to 1000g with lactose, mixed evenly, dry-pressed and granulated, and packaged in d...

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PUM

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Abstract

The invention discloses a medicament for treating children's hyperkinetic symptom, which is prepared from prepared rehmannia root, rhizoma dioscoreae, poria cocos, bark of peony root, oriental water plantain rhizome, polygala root, keel, ligustrum japonicum, corktree bark, anemarrhena rhizome, schisandra fruit and grassleaved sweetflag rhizome. The invention also discloses the process for preparing the medicinal composition and the quality control method.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for treating hyperactivity syndrome in children, a preparation method and quality control thereof, and belongs to the field of traditional Chinese medicines. Background technique [0002] Hyperactivity syndrome in children is called attention deficit hyperactivity disorder (ADHD), mild brain dysfunction syndrome, characterized by hyperactivity, inattention, poor ability to participate in events, but basically normal intelligence . Some children have learning difficulties caused by this. 1% to 3% of school-age children have typical ADHD without symptoms of other diseases; 5% to 10% of school-age children show some ADHD symptoms or are accompanied by problems such as anxiety and depression; 15% to 20% of school-age children may show short-term symptoms , subclinical, or indiscernible ADHD symptoms. The prevalence rate of 14-year-old children is about 7% to 9%, and half of the children...

Claims

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Application Information

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IPC IPC(8): A61K36/8964A61P25/00G01N30/02G01N33/15A61K35/02
Inventor 胥明
Owner 北京凯瑞创新医药科技有限公司
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