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'Shengmai' infusion and its preparation process

A technology of generating pulses and crude drugs, which is applied in drug delivery, pharmaceutical formulations, medical preparations containing active ingredients, etc., and can solve problems such as inconvenient use, heavy workload, and contamination of medicinal liquids

Active Publication Date: 2006-07-12
GUANGDONG YIHETANG PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Purpose of the invention: Based on the above reasons, the present invention has developed a Shengmai infusion product that is easy to use, safe and stable in quality and its preparation method, so as to solve the problems that may occur when using small-scale products in the intravenous administration of Shengmai injection in clinical practice. Problems such as liquid medicine pollution, heavy workload and inconvenient use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0046] Embodiment 1 (10000ml, 250ml / bottle, 40 bottles)

[0047] (1) Ingredients: 80g red ginseng, 249.6g Ophiopogon japonicus, 124.8g schisandra.

[0048] (2) Extraction and purification: Red ginseng is extracted 3 times with 70% ethanol under reflux, each time for 2 hours, the extracts are combined, filtered, ethanol is recovered from the filtrate, 240ml of distilled water is added, refrigerated, filtered, and the filtrate is absorbed by AB-8 macropores Resin chromatography column, first elute with 500ml distilled water, then elute with 70% ethanol, collect the ethanol eluate, recover ethanol, add 240ml water for injection to dissolve, refrigerate, filter, add 2% activated carbon to the filtrate and boil for 30 minutes, cool slightly, Filter until clear to obtain the red ginseng intermediate. The content of total ginsenosides in red ginseng intermediates is determined, and the qualified ones are used for liquid preparation.

[0049] Add water to decoct Ophiopogon japonicu...

Embodiment 2

[0055] Embodiment 2 (1,000,000ml, 250ml / bottle, 4000 bottles)

[0056] (1) Ingredients: Red Ginseng 8kg, Ophiopogon japonicus 24.96kg, Schisandra 12.48kg.

[0057] (2) Extraction and purification: Red ginseng was extracted 3 times with 70% ethanol under reflux, each time for 2 hours, the extracts were combined, filtered, ethanol was recovered from the filtrate, 24L of distilled water was added, refrigerated, filtered, and the filtrate was absorbed by AB-8 macropores Resin chromatography column, first elute with 50L distilled water, then elute with 70% ethanol, collect ethanol eluate, recover ethanol, add 24L water for injection to dissolve, refrigerate, filter, add 2% activated carbon to the filtrate and boil for 30 minutes, cool slightly, Filter until clear to obtain the red ginseng intermediate. The content of total ginsenosides in red ginseng intermediates is determined, and the qualified ones are used for liquid preparation.

[0058] Add water to decoct Ophiopogon japon...

Embodiment 3

[0064] Embodiment 3 (40000ml, 500ml / bottle, 80 bottles)

[0065] (1) Ingredients: 160g red ginseng, 499.2g Ophiopogon japonicus, 249.6g schisandra.

[0066] (2) Extraction and purification: Red ginseng was extracted 3 times with 50% ethanol under reflux, each time for 1 hour, the extracts were combined, filtered, ethanol was recovered from the filtrate, 480ml of distilled water was added, refrigerated, filtered, and the filtrate was absorbed by AB-8 macropores Resin chromatography column, eluted with 1000ml of distilled water first, then eluted with 70% ethanol, collected the ethanol eluate, recovered ethanol, added 480ml of water for injection to dissolve, refrigerated, filtered, and the filtrate was boiled for 30 minutes with 2% activated carbon, slightly cooled, Filter until clear to obtain the red ginseng intermediate. The content of total ginsenosides in red ginseng intermediates is determined, and the qualified ones are used for liquid preparation.

[0067]Add water t...

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PUM

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Abstract

The invention discloses a transfusion for restoring pulse beat, wherein each 1ml of the transfusion contains red ginseng 2-60mg, ophiopogon root 6.24-187.2mg, schisandra fruit 3.12-93.6mg, glucose and / or sodium chloride. The invention also discloses the process for preparing the transfusion.

Description

technical field [0001] The invention belongs to the field of traditional Chinese medicine, and in particular relates to a Shengmai transfusion and a preparation method thereof. Background technique [0002] Shengmai Infusion is an improved formulation of Shengmai Injection, a product already on the market. Shengmai Injection is extracted and refined from red ginseng, Ophiopogon japonicus and Schisandra chinensis. It has the effects of nourishing qi, nourishing yin, and recovering pulse. It is clinically used for palpitations, shortness of breath, and cold limbs due to deficiency of both qi and yin, and weak pulse. , sweating, severe pulse and myocardial infarction, cardiogenic shock, septic shock, etc. with the above syndromes. The specifications of Shengmai injection are 2ml / bottle, 10ml / bottle, 20ml / bottle and 50ml / bottle. The usage and dosage of Shengmai injection are: intramuscular injection (2-4ml once, 1-2 times a day); intravenous infusion (20-60ml once, diluted wit...

Claims

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Application Information

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IPC IPC(8): A61K36/8965A61K9/08A61P9/00A61P9/06A61P9/10
Inventor 王光强刘陶世陈见阳章国林赵新慧敬应春俞国珍徐小军
Owner GUANGDONG YIHETANG PHARMA CO LTD
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