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Antimicrobial compositions

An antibacterial composition and technology of the composition, applied to animal repellents, plant growth regulators, preservation of human or animal bodies, etc.

Inactive Publication Date: 2006-06-28
JANSSEN PHARMA NV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, such combinations usually only show the effect of one antimicrobial agent or obtain only additive effects

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0078] By adding 3-benzo[b]thiophen-2-yl-5,6-dihydro-1,4,2-oxathiazine- 4-oxide and compounds (a)-(m) to prepare antibacterial compositions. Then, test media were prepared by adding aqueous solutions (0.2 ml) of various dilutions of the antibacterial composition to nutrient broth media (10 ml). Each of these test media was inoculated with the above-mentioned bacterial suspension for inoculation (0.1 ml), and then cultured at 30° C. for 24 hours. The presence or absence of bacterial growth was then assessed by visual inspection of the turbidity of the medium. 3-benzo[b]thiophen-2-yl-5,6-dihydro-1,4,2 oxathiazine-4-oxide and compound (a)-( m) The lowest concentration of the mixture is taken as MIC. Tables 1 and 2 list the MICs of various weight ratios of antibacterial compositions for various bacteria.

[0079] [Table 1]

[0080] components

[0081] Note: Compound A: 3-Benzo[b]thiophen-2-yl-5,6-dihydro-1,4,2-oxathiazine-4-oxide

[0082] components

[00...

Embodiment 2

[0085] By adding 3-benzo[b]thiophen-2-yl-5,6-dihydro-1,4,2-oxathiazine to dimethylsulfoxide in the weight ratios listed in Tables 3 and 4 below -4-oxide and compounds (a)-(m) to prepare antibacterial compositions. Then, test media were prepared by adding aqueous solutions (0.3 ml) of various dilutions of the antibacterial composition to nutrient broth media (15 ml). Each of these test media was inoculated with the above-mentioned spore suspension (1 ml) for inoculation, and then cultured at 28° C. for 7 days. The presence or absence of fungal growth in each medium was then assessed by visual inspection. 3-benzo[b]thiophen-2-yl-5,6-dihydro-1,4,2-oxathiazine-4-oxide and compound (a)- (m) The lowest concentration of the mixture is taken as the MIC. Tables 3 and 4 list the MICs of various weight ratios of antibacterial compositions for various fungi.

[0086] components

[0087] Note: Compound A: 3-Benzo[b]thiophen-2-yl-5,6-dihydro-1,4,2-oxathiazine-4-oxide

[0088]...

Embodiment 3

[0091] By adding 3-benzo[b]thiophen-2-yl-5,6dihydro-1,4,2-oxathiazine-4- oxides and compounds (a)-(m) to prepare antibacterial compositions. Then, test media were prepared by adding aqueous solutions (0.1 ml) of various dilutions of the antibacterial composition to Bold's Basal agar medium (15 ml). Each of these test media was inoculated with the above-mentioned algae suspension (1 ml) for inoculation, and then cultured at 25° C. and 1500 lux for 7 days. The presence or absence of algal growth in each medium was then assessed by visual inspection. 3-benzo[b]thiophen-2-yl-5,6-dihydro-1,4,2 oxathiazine-4-oxide and compound (a)-( m) The lowest concentration of the mixture is taken as MIC. Table 5 lists the MIC of each weight ratio of the antibacterial composition for algae.

[0092] components

Minimal inhibitory concentration to Chlorella pyrenoidosa (ppm)

1∶0

3∶1

1∶1

1∶3

0∶1

A: a

40

10

10

10

1...

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PUM

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Abstract

The present invention relates to antimicrobial compositions useful in industrial applications. More specifically, it relates to a process by combining 3-benzo[b]thiophen-2-yl-5,6-dihydro-1,4,2-oxothiazine-4-oxide and one or more options. From 1-[[(3-iodo-2-propynyl)oxy]methoxy]-4-methoxybenzene, 1-chloro-4-[[(3-iodo-2-propynyl)oxy] Methoxy]benzene, zinc 2-pyridinethiol-1-oxide, copper 2-pyridinethiol-1-oxide, sodium salt of 2-pyridinethiol-1-oxide, 2,2-dithio - Bis(pyridine-1-oxide), 2-methylthio-4-tert-butylamino-6-cyclopropylamino-cis-triazole, 2,4,5,6-tetrachloro-1 , 3-phthalonitrile (chlorothalonil), 1,1-dichloro-N-[(dimethylamino)sulfonyl]-1-fluoro-N-phenyl-methanesulfenamide (bacteriozolin) , or 1,1-dichloro-N-[(dimethylamino)sulfonyl]-1-fluoro-N-(4-methylphenyl)-methanesulfenamide (tolylfluanid) combined with Antibacterial compositions of these compounds acting synergistically.

Description

[0001] This application is a divisional application of the Chinese patent application (National Application No. 02806046.6, International Application No. PCT / EP02 / 02368) with the title of "antibacterial composition" filed on March 4, 2002. technical field [0002] The present invention relates to antimicrobial compositions useful for industrial applications. More specifically, it involves the addition of 3-benzo[b]thiophen-2-yl-5,6-dihydro-1,4,2-oxathiazine-4-oxide and one or more From 1-[[(3-iodo-2-propynyl)oxy]methoxy]-4-methoxybenzene, 1-chloro-4-[[(3-iodo-2-propynyl)oxy] Methoxy]benzene, 2-pyridinethiol-1-zinc oxide, 2-pyridinethiol-1-copper oxide, 2-pyridinethiol-1-oxide sodium salt, 2,2-dithio-di (pyridine-1-oxide), 2-methylthio-4-tert-butylamino-6-cyclopropylamino-cis-triazole, 2,4,5,6-tetrachloro-1,3 -phthalonitrile (Chlorothalonil), 1,1-Dichloro-N-[(dimethylamino)sulfonyl]-1-fluoro-N-phenyl-methanesulfinamide (Zifenil), or 1,1-Dichloro-N-[(dimethylamino)sulfonyl]-1...

Claims

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Application Information

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IPC IPC(8): A01N43/40A01N31/14A01N31/16A01N41/04A01N43/64A01N43/647A01N43/70A01N43/80A01N43/88
CPCA01N43/88A01N59/20A01N59/16A01N47/12A01N47/04A01N43/80A01N43/70A01N43/40A01N37/34A01N31/16A01N2300/00
Inventor T·奥尼施I·塔纳卡
Owner JANSSEN PHARMA NV
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