Application of magnolia vine fruit in preparation of anti-tumor medicine or multi-medicine tolerant reversal agent

A technology for anti-tumor drugs and multi-drug resistance, applied in anti-tumor drugs, drug combinations, pharmaceutical formulations, etc., can solve problems that hinder clinical application, no anti-tumor reports, no anti-tumor multi-drug resistance, etc.

Inactive Publication Date: 2006-04-26
高陈勇
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Its calcium antagonistic activity on blood vessels and myocardium has nothing to do with its MDR reversal effect, but is related to the side effects of the cardiovascular system, and its side effects seriously hinder clinical application
[0006] Schisandra chinensis, the dry mature fruit of Schisandra chinensis (Turcz.) Baill. or Schisandra sphenanthera Rehd.et Wils. , Yiqi Shengjin, tonifying the kidney and calming the heart, is a nourishing and strong medicine commonly used in traditional Chinese medicine, and has a variety of pharmacological effects, but there are no clear reports of anti-tumor, especially no reports of anti-tumor multi-drug resistance

Method used

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  • Application of magnolia vine fruit in preparation of anti-tumor medicine or multi-medicine tolerant reversal agent
  • Application of magnolia vine fruit in preparation of anti-tumor medicine or multi-medicine tolerant reversal agent
  • Application of magnolia vine fruit in preparation of anti-tumor medicine or multi-medicine tolerant reversal agent

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Embodiment 1: the extraction of Schisandra chinensis

[0033] Reflux method:

[0034](a) take Schisandra chinensis 15000g as raw material;

[0035] (b) Crushing the fruit of Schisandra chinensis into coarse powder, soaking in 4 times the amount of 90% ethanol for 12 hours. The concentration of ethanol required here can be 50% to 100%, usually 70% to 90% ethanol is selected as the extractant, and the soaking time can be 6 to 24 hours.

[0036] (c) extracting the schisandra ethanol soaking solution in step (b) for 3 hours at reflux temperature, filtering, and collecting the filtrate;

[0037] (d) Add 3 times the amount of 90% ethanol to the filter residue in step (c), extract at reflux temperature for 2 hours, filter and collect the filtrate;

[0038] (e) add 3 times the amount of 90% ethanol to the filter residue in step (d), extract at reflux temperature for 2 hours, filter and collect the filtrate;

[0039] (f) Combine the filtrates collected in (c), (d) and (e), r...

Embodiment 2

[0041] Embodiment 2: the extraction of Schisandra chinensis

[0042] Percolation method: take 5000g Schisandra chinensis powder and percolate with 6 times the amount of 95% ethanol at a percolation speed of 15ml / min. Recover the ethanol leachate, recover the ethanol under reduced pressure until there is no ethanol smell, concentrate to obtain an extract with a specific gravity of 1.15 g / ml, and set aside. The above ethanol can also be replaced by various alcohols such as methanol and propanol; it can also be replaced by other organic solvents such as ethyl acetate and ether solvents.

Embodiment 3

[0043] Embodiment 3: the extraction of Schisandra chinensis

[0044] Supercritical extraction: crush 1000 g of the schisandra sample into a coarse powder (through a 40-mesh sieve), put 1L of supercritical CO 2 In the extraction kettle, adjust the pressure: 25MPa, temperature: 45°C, flow rate: 30kg / h, extraction time: 2h. A brown extract was collected.

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PUM

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Abstract

The invention provides the use of schisandra fruit in preparing medicament for treating tumors, wherein the schisandra is a plant of Schisandra chinesis(Turcz.)Baill. belonging to Magnoliales, it can effectively inverse the multi-drug tolerance of the tumors. The extracts of schisandra fruit can be acted on P-glucoprotein, MRP1 and MXR.

Description

(1) Technical field [0001] The invention relates to the definite application of the Chinese herbal medicine Schisandra chinensis in the preparation of drugs for treating tumors, especially the application of Schisandra chinensis in the preparation of anti-tumor cell multidrug resistance reversal agents. (2) Background technology [0002] Tumor is one of the main causes of human death, and tumor chemotherapy is a major means of treating tumors. However, cancer chemotherapy will fail because tumor cells acquire drug resistance. [0003] There are many reasons for the multidrug resistance of tumor cells, the most important of which is the expression of ATP-binding transporters [ATP binding cassette (ABC) transporters] in tumor cells. P-glycoprotein (P-glycoprotein, P-gp), multidrug resistant associated protein 1 (MRP1) and breast cancer resistance protein (BCRP, also known as MXR or ABCG2), It is currently recognized as several major proteins that lead to tumor multidrug resi...

Claims

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Application Information

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IPC IPC(8): A61K36/79A61P35/00A61K131/00
Inventor 胡汛
Owner 高陈勇
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