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Preparation process of active medicinal lignin matter and its use in treating cardiac vascular diseases

A technology of active substances and lignin, which is used in the field of medical and pharmaceutical industries

Active Publication Date: 2010-05-26
溧阳常大技术转移中心有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

But there is no report as a treatment for cardiovascular and cerebrovascular diseases, such as US Patent Application 20040048804

Method used

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  • Preparation process of active medicinal lignin matter and its use in treating cardiac vascular diseases
  • Preparation process of active medicinal lignin matter and its use in treating cardiac vascular diseases

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Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0012] 1. Preparation of lignin medicinal active substances

[0013] Birch, basswood, and oak are used as raw materials to prepare lignin-based active substances. The birch, basswood, and oak are peeled and cut into wood chips, which are extracted with water vapor in an alkaline environment. A batch of materials is continuously processed within 12 hours. Extraction ends at PH14, and different fractions are extracted according to the change of PH in different time; each fraction solution prepared above is subjected to forced oxidative degradation by membrane electrolysis in the presence of polysaccharase, and the oxidative degradation solution is degraded from PH14 to between PH3 ;The degradation liquid is preliminarily separated by dialysis, reverse osmosis, ultrafiltration and other methods, and the forced oxidation degradation liquid with a molecular weight of <4000 and a pH value of 3 is put into the reactor and reacted under constant stirring. The reaction temperature is 4...

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Abstract

The present invention relates to medicine industry, and is especially preparation process of active medicinal lignin matter with birch, basswood, oak and other broad-leaved tree material. The preparation process of the active medicinal lignin matter includes barking, cutting, water steam extraction under alkali environment, membrane electrolysis to forced oxidation and degradation to obtain degraded liquid of pH 3, separating the degraded liquid via dialysis, inverse soaking, ultrafiltering, etc to eliminate low molecular weight components below 300, filtering to separate out solid as the active lignin-polysaccharide matter, and taking the medicinal active matter of molecular weight 1000-4000 for treating cardiac and cerebral vascular diseases. The prepared medicinal active matter has highcardiac and cerebral vascular disease treating effect.

Description

technical field [0001] The invention relates to the medical and pharmaceutical industry, in particular to a preparation method of a lignin medicinal active substance and its use in the preparation of medicines for treating cardiovascular diseases. Background technique [0002] Lignin is a kind of polymer with phenylpropane monomer as the skeleton and a network structure, and is one of the main components of plant cell walls. Due to different types of plants, different growth environment regions, and different extraction methods used, the molecular weight and molecular structure of lignin obtained are also different, resulting in different uses of lignin. At present, the application and research of lignin at home and abroad are mainly in: (1) The direct concentration of lignin from papermaking waste liquid can be used as fuel. (2) Lignin products are mainly used in reports on mud water reducer, oil field drilling mud pour point depressant, rubber reinforcing agent, etc. [...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/74A61P9/00
Inventor 张静徐鸽杨扬
Owner 溧阳常大技术转移中心有限公司
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