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Application of penehyclidine hydrochloride in preparing medicine

A technology of penehyclidine hydrochloride and drug administration, which is applied in the direction of drug delivery, drug combination, and medical formula, which can solve the problems that have been discovered and confirmed before, and have not found medical clinical effects, so as to reduce stiffness and tremor Symptoms, suppression of salivation and excessive sweating, the effect of obvious curative effect

Inactive Publication Date: 2006-03-01
CHENGDU LIST PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Prior to this, penehyclidine hydrochloride has been found and confirmed to have the efficacy and clinical efficacy of rescuing organophosphate poisoning, but no other medical clinical effects have been found

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] The application of the present invention in the preparation of medicaments for treating gastrointestinal diseases includes: A, the therapeutic application of peptic ulcer; Therapeutic application of hypermotility of the small intestine, dysentery and rectal irritation; C, inhibition of saliva secretion, salivation of Parkinson's disease, and saliva dysphagia caused by esophageal mechanical obstruction.

[0035] Medication can be taken orally, intramuscularly or intravenously, and the preferred dosage range is 0.01-10mg / time.

Embodiment 2

[0037] The application of the present invention in ophthalmic diseases in clinical medicine includes: A, pupil dilation, fundus examination, and iritis, keratitis, and anti-adhesion treatment applications; B, application for regulating paralysis in optometry.

[0038] The dosage form can be selected as eye drops or eye paint, and the preferred concentration is 0.03-3%.

Embodiment 3

[0040] The clinical application of the present invention in respiratory diseases includes: A, the application of relieving cold and acute and chronic rhinitis; B, the application of relieving asthma.

[0041] The dosage forms can be nasal drops or sprays, and the preferred concentration is 0.025-2.8.

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PUM

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Abstract

he present invention relates to the application of penehyclidine hydrochloride in preparing medicine, and is especially the application of penehyclidine hydrochloride in preparing pre-narcosis medicine. Animal experiment and clinical observation prove the obvious gland secretion inhibiting effect of penehyclidine hydrochloride as pre-narcosis medicine. The present invention expands the medicinal use of penehyclidine hydrochloride.

Description

Technical field: [0001] The invention relates to the application of penehyclidine hydrochloride, in particular to the application of penehyclidine hydrochloride in clinical medicine for gastrointestinal diseases, eye diseases, respiratory diseases, central nervous system diseases, anesthesia, urogenital tract renal colic and bladder irritation Syndrome, anti-septic shock, anti-biliary colic, etc. Background technique: [0002] Penehyclidine hydrochloride, English name: Penehyclidine Hydrochloride, its chemical name is 3-(2-cyclopentyl-2-hydroxy-2-phenylethoxy)quinuclidine hydrochloride, molecular formula: C 20 h 29 NO 2 • CH1, molecular weight: 351.92. Prior to this, penehyclidine hydrochloride has been found and confirmed to have the efficacy and clinical efficacy of rescuing organophosphate poisoning, but no other medical clinical effects have been found. Invention content: [0003] The purpose of the present invention is to propose new indications of penehyclidine h...

Claims

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Application Information

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IPC IPC(8): A61K31/495A61K9/08A61K9/12A61P43/00A61P23/00
Inventor 倪友洪蒲春霞雍萍曹勇王卫国
Owner CHENGDU LIST PHARMA
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