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Application of enkephalin of methionine, and method of application

A technology of methionine enkephalin and blood, applied in the field of methionine enkephalin to treat tumors, can solve the problem that the effect of methionine enkephalin cannot be fully exerted, and achieve outstanding anti-tumor effect, good safety and low production cost Effect

Inactive Publication Date: 2006-02-01
黄建寅
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0013] The above-mentioned records about the use of methionine enkephalin are all directly acting on the human body, and the effect of methionine enkephalin can not be brought into full play. Therefore, the method of treating tumor diseases with methionine enkephalin is still in the experimental stage

Method used

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Examples

Experimental program
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Effect test

Embodiment 1-3

[0033] The specific steps of the method embodiment 1-3 in the method of treating blood in the tumor biotherapy with the drug containing methionine enkephalin include:

[0034] (1) adding methionine enkephalin solution to blood; the concentration of methionine enkephalin solution is 0.01-1 mg / ml, and the weight ratio of blood and methionine enkephalin solution is 1: 0.1-0.2;

[0035] (2) Cultivate at 0°C-40°C for 1-14 days;

[0036] (3) To be imported into the human body.

Embodiment 4-7

[0037] The specific steps of the method embodiment 4-7 in the method for treating blood in tumor biotherapy with methionine-enkephalin drugs include:

[0038] (1) add methionine enkephalin solution in blood; The concentration of methionine enkephalin solution is 0.01-1 mg / ml, and the weight ratio of blood and methionine enkephalin solution is 1: 0.1-0.2, and cytokine addition is 100,000-1,000,000 units / ml blood;

[0039] (2) Cultivate at 0°C-40°C for 1-14 days;

[0040] (3) To be imported into the human body.

[0041] methionine enkephalin

[0042] The embodiment of the present invention has been studied through animal experiments, and the results show that: after the blood is reinfused into the body of a tumor patient, the methionine enkephalin can stimulate the immune system well. Experimental conclusion: CD3, CD4, CD8 and NK cells in these patients all increased greatly. The tumors of cancer patients have obvious shrinkage phenomenon, and the tumors of some c...

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Abstract

An application of methionine enkephalin in preparing the medicine for treating the blood in biotherapy of tumor is disclosed. Its treating method includes a culture step after said medicine is added to the blood to be treated for reproducing more cellulotoxic cells, macrophages, natural killing cells, interleukin-2, and gamma-interferons, resulting in higher power to kill tumor cells.

Description

technical field [0001] The invention relates to the technical field of treating tumors, in particular to the technical field of treating tumors with biological therapy and the technical field of treating tumors with methionine enkephalin. Background technique [0002] Neoplastic diseases, including cancer, are one of the leading causes of human death. At present, there are many methods for treating tumors, including tumor biotherapy and using methionine enkephalin as a drug for treating tumors. [0003] The steps of the existing tumor biotherapy method include: 1. Extracting blood from the body of a normal person or a tumor patient; 2. Aseptically separating the extracted blood in vitro to obtain lymphocytes, stem cells, natural killer cells, monocytes, etc. 3. Cultivate and process the extracted blood outside the body; 4. Transfuse the processed blood into the tumor patient. Since the cultivation and processing of the blood are carried out outside the body, the cultivatio...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61M1/00A61M1/36A61K38/08A61K38/19
Inventor 黄建寅
Owner 黄建寅
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