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Optical tweezers Raman spectrograph with high sensitivity

An optical tweezers Raman and high-sensitivity technology, applied in the field of Raman spectrometers, can solve the problems of large fluorescence signal, weak Raman scattering signal, and large influence of Raman scattering signal, achieving wide application prospects, improving signal-to-noise ratio, The effect of improving sensitivity

Inactive Publication Date: 2005-12-28
SHANGHAI INST OF OPTICS & FINE MECHANICS CHINESE ACAD OF SCI
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Problems solved by technology

[0005] (1) Because of ordinary Raman scattering, its Raman scattering signal is very weak, especially for biological samples such as cells, bacteria, and viruses
[0006] (2) Although the fluorescence signal has decreased, it is still relatively large, which has a great impact on the Raman scattering signal
[0007] (3) The signal-to-noise ratio of Raman spectroscopy is not high enough

Method used

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  • Optical tweezers Raman spectrograph with high sensitivity
  • Optical tweezers Raman spectrograph with high sensitivity
  • Optical tweezers Raman spectrograph with high sensitivity

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Embodiment Construction

[0030] see figure 2 , figure 2 It is a schematic diagram of the optical path of an embodiment of the high-sensitivity optical tweezers Raman spectrometer of the present invention. As can be seen from the figure, the composition of the high-sensitivity optical tweezers Raman spectrometer of the present invention includes a pumping optical path, a detection optical path, a visible light illumination optical path and an observation optical path. The pumping optical path includes a pump laser 1, and the output of the pump laser 1 The advancing direction of the optical path is successively the narrowband filter 2, the beam combiner 3, the first beam splitter 4, the dichroic mirror 5, the objective lens 6, the sample stage 7, and the described beam combiner 3, the first beam splitter 4 and the The dichroic mirror 5 is parallel and placed at 45° to the optical path, so that the optical path is twisted and turned, and the parallel light beam output by the pump laser 1 advances alon...

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Abstract

A Raman spectrograph of light tweezers with high sensitivity consists of pumping light path, detecting light path , lighting path of visible light and viewing light path . It features that laser emitted from Stoket laser is unified with pumping light through beam unifier and unified beam reacts on sample to be tested for generating coherent counter - Stoket Raman scatter.

Description

technical field [0001] The invention relates to a Raman spectrometer, in particular to a high-sensitivity optical tweezers Raman spectrometer combining coherent anti-Stokes Raman scattering (CARS) and optical tweezers technology. It can be widely used in cell biology and medical research, and can study the dynamic change process of a single living cell and identify cancer cells and normal cells. Background technique [0002] The combination of Raman spectroscopy and optical tweezers is an active research direction in recent years. [0003] Prior art: a near-infrared Raman spectrometer (Yong-qing Li et al. Opt. Lett. 27 (4), 249-251, 2002) of a single light-capturing cell, the optical path of which is as follows figure 1 shown. A beam of semiconductor laser 1 with a wavelength of 785nm is filtered by a narrow-band filter 2, passes through a mirror 3, a notch filter 4 (HNF), and a dichromatic mirror 5, and then is focused on a sample stage 7 by an objective lens 6, forming a...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/65
Inventor 魏青邓见辽
Owner SHANGHAI INST OF OPTICS & FINE MECHANICS CHINESE ACAD OF SCI
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