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Extraction of aromatic turmeric alcohol

A technology of curcuma alcohol and curcuma oil is applied in the field of extraction technology of curcuma alcohol, which can solve the problems of inability to meet industrialized large-scale production, cannot be transplanted and enlarged, and large loss of curcuma alcohol, and achieves common equipment, small extraction loss, and large extraction volume. Effect

Inactive Publication Date: 2005-12-28
HONGGUAN BIO PHARMA CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, the extraction efficiency of the above-mentioned process is low, the yield is small, and the extraction period is long. In the process, the loss of curcumol is huge, so it cannot be transplanted and enlarged, and cannot meet the needs of industrialized large-scale production.
[0009] But, so far, there is no other report about extracting curcumol in a large amount from zedoary oil, and based on the above reasons, the present invention has carried out detailed research on the extraction process of curcumol

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] Put 500ml of zedoary oil into a 2000ml single-neck round bottom flask, connect a 60cm fractionation column to the top, connect a condenser to the outlet of the fractionation column, connect a thermometer to the top, connect the whole device to a vacuum pump, turn on the vacuum pump, and heat slowly, when the vacuum degree reaches 20mmHg, when the temperature of the escaping gas reaches 158°C, a solid-liquid mixture begins to flow out from the outlet of the condenser until 162°C, the solids slip out completely, collect this fraction, filter the solid, and wash the filtered solid with petroleum ether for several times , until colorless, recrystallized with 4 times the amount of anhydrous ether-petroleum ether (3:7), to obtain 184 g of colorless needle-shaped curcumol crystals with a content of 96.4%, and the yield was 36.8%.

Embodiment 2

[0031] Put 200ml of zedoary oil into a 1000ml round bottom flask, connect a 50cm fractionation column to the top, connect a condenser to the outlet of the fractionation column, connect a thermometer to the top, connect the whole device to a vacuum pump, turn on the vacuum pump, and heat slowly, when the vacuum reaches 30mmHg, When the temperature of the escaping gas reaches 165°C, a solid-liquid mixture begins to flow out from the outlet of the condenser until 170°C, when the solid slips out completely, collect this fraction, filter the solid, and wash the filtered solid with petroleum ether several times until Colorless, recrystallized with 6 times the amount of anhydrous diethyl ether-petroleum ether (3:7), to obtain 60.2 g of colorless needle-shaped curcumol crystals with a content of 97.2%, and a yield of 30.1%.

Embodiment 3

[0033] Put 500ml of zedoary oil into a 2000ml single-neck round bottom flask, connect a 60cm fractionation column to the top, connect a condenser to the outlet of the fractionation column, connect a thermometer to the top, connect the whole device to a vacuum pump, turn on the vacuum pump, and heat slowly, when the vacuum degree reaches 15mmHg, when the temperature of the escaping gas reaches 153°C, a solid-liquid mixture begins to flow out from the outlet of the condenser tube, until 157°C, the solid slips out completely, collect this fraction, filter the solid, and wash the filtered solid with petroleum ether for several times , until it was colorless, recrystallized with 7 times the amount of absolute ethanol to obtain 154 g of colorless needle-shaped curcumol crystals with a content of 96.5%, and the yield was 30.8%.

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Abstract

Extraction of zedoary alcohol is carried out by vacuum split-flowing for zedoary oil, flowing out solid-liquid mixture at some vacuum degree and temperature, collecting the fraction, re-crystallizing for the filtered solid from organic solvent or mixed solvent, and obtaining colorless needle crystal zedoary alcohol. Its advantages include simple process, higher recovery rate and purity.

Description

technical field [0001] The invention relates to an extraction method for extracting a single active ingredient from volatile oil of natural medicinal plants, in particular to a method for extracting curcumol from zedoary volatile oil. Background technique [0002] Curcuma is the rhizome of Zingiberaceae plants Pengzezhu, Guangxi Curcuma or Wencurcuma. Bitter in the mouth, pungent, warm in nature. Traditional Chinese medicine believes that it has the effects of promoting qi and breaking blood, eliminating accumulation and relieving pain. Modern pharmacological studies have shown that zedoary volatile oil has the functions of directly inhibiting and destroying cancer cells, enhancing immune activation, regulating immune response, and promoting whitening. It is an effective material basis for zedoary to treat tumors. Zedoary oil is the volatile oil of Zedoary, which is obtained by steam distillation of Zedoary. It is used to treat cervical cancer and has been included in the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D307/77
Inventor 孟昭珂付美珍
Owner HONGGUAN BIO PHARMA CO LTD
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