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Compsn. of medication for treating high blood pressure

A composition and technology of high blood pressure, applied in the direction of drug combination, pharmaceutical formula, cardiovascular system diseases, etc., can solve problems such as poor prognosis, unknown pathogenic factors, and many complications

Inactive Publication Date: 2005-11-16
苏金平
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are the following problems: first, the main pathogenic factors of most diseases are unknown; second, most diseases have more complications; third, even if the etiology is known, it is almost impossible for a chemical component to inhibit all causes
However, as hypertension is a disease with uncertain etiology, the cure rate of drugs targeting one or more effects of one etiology or mechanism of action is relatively low. Usually, the cure rate of one drug is about 40-50%, and poor prognosis
In recent years, although there are many new antihypertensive drugs with good curative effect and few side effects, the blood pressure control rate can only reach 50-60%

Method used

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  • Compsn. of medication for treating high blood pressure
  • Compsn. of medication for treating high blood pressure
  • Compsn. of medication for treating high blood pressure

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0049] Furosemide 5mg, calcium gluconate 2000mg, sucrose 350mg, starch 45mg.

Embodiment 2

[0051] Hydrochlorothiazide 6.25mg, calcium gluconate 2000mg, sucrose 350mg, starch 43.75mg.

Embodiment 3

[0053] Indopamide 1.0mg, calcium citrate 2000mg, sucrose 350mg, starch 49mg.

[0054] It is worth mentioning that the dosage of calcium is based on Ca 2+ It is added in proportion to the calcium-containing component.

[0055] W Ca2+ =W HF *(M ca2+ / M HF *100%)

[0056] W Ca2+ Indicates the amount of calcium;

[0057] W HF Indicates the amount of calcium-containing components in the formula;

[0058] m ca2+ / M HF *100% indicates the percentage of calcium in the calcium-containing component.

[0059] The beneficial effects of the composition of the present invention in the preparation of medicines for treating hypertension will be further illustrated below through animal experiments and human observations. attached Figures 1 to 5 Based on the experimental results of the furosemide+calcium group; attached Figures 6 to 10 Based on the experimental effect of hydrochlorothiazide + calcium group.

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PUM

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Abstract

A composite medicine for treating hypertension contains the diuretic chosen from errolon, ethacrynic acid, bumetanide, chlorothiazinde, hydrochlorothiazinde, etc a Ca-contained component chosen from shell, inorganic Ca salt, organic Ca salt, etc, and the pharmacologically acceptable additives.

Description

technical field [0001] The present invention relates to a pharmaceutical composition, more specifically, the present invention relates to a pharmaceutical composition for treating hypertension. Background technique [0002] Hypertension is one of the most common cardiovascular diseases at present. It is mainly manifested clinically by increased systemic arterial pressure, often accompanied by various complications such as stroke, myocardial infarction, heart failure, coronary heart disease, and diabetes. Europe and North America are high incidence areas of hypertension. Surveys show that the prevalence of hypertension among adults in my country is 18.8%. It is estimated that the number of patients nationwide is 160 million, an increase of more than 70 million compared with 1991. The prevalence of hypertension in rural areas is rising rapidly, and the gap between urban and rural areas is not obvious. Generally speaking, the life expectancy of hypertensive patients is 15-20 y...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/341A61K31/549A61K45/06
CPCA61K31/341A61K31/549A61K45/06A61P9/12A61K2300/00
Inventor 彭继道刘丽笙苏金平杨家秀
Owner 苏金平
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