Novel effectors of dipeptidyl peptidase IV
A dipeptidyl peptidase and effector technology, applied in the field of new effectors of dipeptidyl peptidase IV, can solve problems such as side effects
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[0030] In the present invention, oral administration of high-affinity low-molecular-weight enzyme inhibitors is an economical alternative to widely used surgical techniques in the treatment of pathological conditions. Through chemical design for stability, transport and clearance properties, the mode of action can be adjusted and adapted to the characteristics of different individuals.
[0031] As mentioned above, for example in the case of long-term treatment of diabetes, it may be necessary to provide effectors with said activity which can meet the different requirements of the patients and treat their symptoms. The said dipeptide compound of the present invention shows that at a (dipeptide compound) concentration of 10 micromolar, especially under the conditions shown in Table 1, dipeptidyl peptidase IV or class DP IV enzyme activity is reduced by at least 10%, especially is at least 40% lower. Usually a reduction of at least 60% or 70% is also required. Preferred effecto...
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