A method for treating viral diseases and other disorders by altering immediate gene expression through administration of peptide T

Abstract

A method for inhibiting viral replication and for treating neurotrophic conditions by modulating / suppressing immediate early gene expression in a host cell comprising administering a modulating / suppressing effective amount of formula (I) in a physiologically suitable carrier The peptide or its derivatives: Ra-Ser-Thr-Thr-Thr-Asn-Tyr-Rb, Ra represents the amino terminal residue Ala or D-Ala and Rb represents the carboxyl terminal residue Thr or Thr amide, the formula ( I) Peptide derivatives add a Cys residue at one or both ends of the amino and carboxyl groups, or a peptide or derivatives of the formula (II): R1-R2-R3-R4-R5, R1 is the amino-terminal residue Thr, Ser, Asn, Glu, Arg, Ile or Leu, R2 is Thr, Ser or Asp, R3 is Thr, Ser, Asn, Arg, Gln, Lys or Trp, R4 is Tyr and R5 is preferably the carboxy-terminal residue Thr , Arg or Gly, the derivative of the peptide of formula (II) has the corresponding D-amino acid as the amino terminal residue, and / or the corresponding amide derivative as the carboxyl terminal residue, and / or at the amino and carboxyl terminal A Cys residue is appended to one or both ends of .

Description

[0001] Refer to related application [0002] This application claims priority to US Provisional Patent Application 60 / 164,363, filed November 9,1999. technical field [0003] The present invention relates to antiviral therapy, ie, the inhibition of viral replication by altering immediate gene expression in infected cells, and to methods of modulating immediate gene expression for the treatment of other disorders. technical background [0004] It has been found that T-peptide and its analogs help to alleviate some AIDS symptoms by inhibiting the binding of HIV antigen to CD4 receptor. See US Patents 5,863,718, 5,834,429 and 5,276,016. In addition, T-peptides have been found beneficial in the treatment of various other diseases and conditions, generally due to their ability to bind receptors. T-peptide has also been implicated that inhibition of gp120 induces an increase in somatostatin, and an increase in somatostatin can lead to the release of growth hormone releasing horm...

AI Technical Summary

Problems solved by technology

Furthermore, lack of required gene transcription and translation can allow host cell responses to be temporally controlled by depleting the cellular pool of transcription factors.

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