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Finger print allas used for controlling isatidis root, its preparation quality and medicine effect and its making method

A fingerprint, Radix isatidis technology, applied in the direction of testing pharmaceutical preparations, testing food, material inspection products, etc., can solve the problem of invalid and ineffective judgment of the presence or absence of Radix isatidis, the quality of Radix isatidis can not be distinguished, etc., to achieve the effect of simple operation

Active Publication Date: 2005-03-09
GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Chinese Patent Application No. 01119925.3 "Method for Establishing the Fingerprint of Salvia Miltiorrhiza Medicinal Material" is the fingerprint of the high-performance liquid chromatography set up for the water-soluble extract of Salvia miltiorrhiza. It is ineffective for another medicinal material with a different composition
[0006] It can be seen from the above that at present, the quality of Radix isatidis and its preparations has no real controllable technology, and it is impossible to effectively judge the presence or absence of Radix isatidis in the preparation of Radix isatidis, and it is impossible to distinguish the medicinal materials of Radix isatidis from different origins and evaluate its quality. pros and cons

Method used

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  • Finger print allas used for controlling isatidis root, its preparation quality and medicine effect and its making method
  • Finger print allas used for controlling isatidis root, its preparation quality and medicine effect and its making method
  • Finger print allas used for controlling isatidis root, its preparation quality and medicine effect and its making method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0042] Take Radix isatidis medicinal material from a real estate in Anhui, grind it into powder, take 1.0g of powder, add 50ml of distilled water, ultrasonically extract for 30min, filter, take 20ml of the filtrate, evaporate to dryness, dissolve in methanol to a volume of 10ml, and analyze according to the above-mentioned chromatographic method , making the fingerprint of the medicinal material, and at the same time, quantitatively analyzing the content of adenosine, guanosine and uridine, the fingerprint is as follows figure 2 shown. The contents of adenosine, guanosine and uridine are respectively: 472, 98 and 363 μg / g. The content of adenosine and uridine in the active parts of the medicinal materials in this place is relatively high, 2, 5, 6, 7, 8, 9, Peak No. 10 has a large peak value and is very obvious, which is the main chromatographic peak in the spectrum. Except for No. 1 and No. 3 chromatographic peaks, other chromatographic peaks are all higher than the Radix Ra...

Embodiment 2

[0044] Take Radix isatidis medicinal material from a real estate in Northeast China, grind it into powder, take 1.0g of powder, add 50ml of distilled water, ultrasonically extract for 30min, filter, take 20ml of the filtrate, evaporate to dryness, dissolve in methanol to 10ml, and analyze according to the above-mentioned chromatographic method , making the fingerprint of the medicinal material, and at the same time, quantitatively analyzing the content of adenosine, guanosine and uridine, the characteristics of the entire fingerprint are as follows Figure 6 shown. The contents of adenosine and uridine were 132 and 326 μg / g, respectively, and guanosine could not be detected. Judging from the overall characteristics of the fingerprints of the active parts of the medicinal materials in this place of origin, there are few chromatographic peaks with large peaks. The content of uridine is relatively high, and the peaks of No. 2, 6, and 9 are large and obvious, which are the main ch...

Embodiment 3

[0046] Take Radix isatidis medicinal material from a real estate in Sichuan, grind it into powder, take 1.0g of the powder, add 50ml of distilled water, ultrasonically extract for 30min, filter, take 20ml of the filtrate, evaporate to dryness, dissolve in methanol to a volume of 10ml, and analyze according to the above-mentioned chromatographic method , making the fingerprint of the medicinal material, and at the same time, quantitatively analyzing the content of adenosine, guanosine and uridine, the fingerprint is as follows Figure 7 shown. The contents of adenosine, guanosine and uridine are respectively: 236, 82 and 123 μg / g. The content of adenosine in the active parts of the medicinal materials in this place is relatively high, the peaks of each chromatographic peak are small, and the content of active ingredients Low. Judging from the overall characteristics of the fingerprints of the active parts of the medicinal materials in this place of origin, the peaks of each ch...

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Abstract

The present invention relates to a fingerprint for controlling quality of Chinese medicinal material isatis root and its medicinal preparation and its making method. Said invented fingerprint is one of antiviral active site in Chinese medicinal material isatis root, and said active site uses nucleosides as main composition portion, in which the known nucleoside components have adenosine, uridine and guanosine. Said invention utilizes the creation of fingerprint of active site of isatis root and combines it with quantitative analysis result of index components so as to comprehensively evaluate the quality and medicinal effect of isatis root and its medicinal preparation, and can make the quality of isatis root and its medicinal preparation have true controllable standard.

Description

technical field [0001] The invention relates to a technique for controlling the quality of Radix Radix Radix Radix and Radix Radix Radix preparation by utilizing the fingerprint of the antiviral active part of Radix Radix Radix Radix. Background technique [0002] Isatis root is the root of the cruciferous plant Isatis indigo, which has the effects of clearing away heat and detoxification, cooling blood and relieving throat, and is used for viral infections. The quality control methods of Radix isatidis and its preparations recorded in "Chinese Pharmacopoeia" and the standards issued by the Ministry of Health all use the identification of amino acids and the presence or absence of fluorescence to control the internal quality. The identification reaction of this fluorescence and amino acid is difficult to reach the purpose of controlling its internal quality again, because, wherein two identification reactions can't confirm that the medical material used in the preparation is...

Claims

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Application Information

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IPC IPC(8): G01N33/02G01N33/15
Inventor 曾令杰李楚源陈矛王德勤陈薇
Owner GUANGZHOU BAIYUSN HUTCHISON WHAMPOA CHINESE MEDICINE
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