Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

2-(4-isobutylphenyl) propionic acid medicinal composition

A kind of composition and medicine technology, applied in the pharmaceutical composition of aqueous solution, the pharmaceutical composition of amino acid is arginine, the field of manufacture of pharmaceutical composition containing arginine and ibuprofen aqueous solution

Inactive Publication Date: 2005-02-23
CUMBERLAND PHARM INC
View PDF7 Cites 32 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0011] However the method described in the aforementioned patent has the disadvantage that it needs to be formulated into a salt and then dissolved, but the salt must be isolated and tested before the dosage form can be produced

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • 2-(4-isobutylphenyl) propionic acid medicinal composition
  • 2-(4-isobutylphenyl) propionic acid medicinal composition
  • 2-(4-isobutylphenyl) propionic acid medicinal composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] Add 8.2 kg of arginine to approximately 80 liters of water for injection and mix until dissolved. Add 10.0 kg of ibuprofen to the arginine solution and mix until dissolved. Sufficient water was added to bring up to 100 liters to produce a 100 mg / ml solution with a molar ratio (arginine: ibuprofen) of 0.92:1. The resulting product was a clear, colorless solution that readily passed through a 0.2 micron filter. The pH of the resulting solution was about 7.4 and could be adjusted to slightly higher or lower pH as needed. The solution can be further sterilized at the end to minimize the possibility of the product not being sterilized.

Embodiment 2

[0022] Lower concentrations of ibuprofen can be prepared using lower amounts of arginine and ibuprofen. Add 41 g of arginine to approximately 80 liters of water for injection and mix until dissolved. Add 50 g of ibuprofen to the arginine solution and mix until dissolved. Sufficient water was added to bring up to 100 liters to produce a 0.5 mg / ml solution with a molar ratio (arginine:ibuprofen) of 0.92:1. The resulting product was a clear, colorless solution that readily passed through a 0.2 micron filter. The pH of the resulting solution can be adjusted to achieve the desired pH.

Embodiment 3

[0024] Lower concentrations of arginine can be used to prepare ibuprofen solutions. Add 3.8 kg of arginine to approximately 80 liters of water for injection and mix until dissolved. Add 7.5 kg of ibuprofen to the arginine solution and mix until dissolved. Sufficient water was added to bring up to 100 liters to produce a 75 mg / ml solution with a molar ratio (arginine:ibuprofen) of 0.60:1. The product can be passed through a 0.2 micron filter to give a clear colorless solution. The pH of the resulting solution can be adjusted to achieve the desired pH.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present invention provides a pharmaceutical composition comprising an aqueous solution of arginine and ibuprofen, wherein the molar ratio of arginine to ibuprofen is less than 1:1, as well as a method of making the same. The present invention also provides a method of treating a condition chosen from pain, inflammation, fever, and / or other conditions alleviated by ibuprofen comprising administering a pharmaceutical composition comprising an aqueous solution of arginine and ibuprofen, wherein the molar ratio of arginine to ibuprofen is less than 1:1.

Description

[0001] The present invention relates to a pharmaceutical composition containing 2-(4-isobutylphenyl)propionic acid and basic amino acid, more specifically arginine, for oral or injection (parenteral). Background of the invention [0002] 2-(4-isobutylphenyl) propionic acid, its international non-patent trade name is ibuprofen (ibuprofen), is a kind of well-known anti-inflammatory substance, molecular weight is 206.28, has following chemical structural formula: [0003] [0004] (Merck Index 12th ed., n4925, p 839). Since originally patented in the 1960's, ibuprofen is now marketed generically under the trade names Motrin(R), Advil(R), Advil(R), and Nuprin(R) for the treatment of pain, inflammation and fever. [0005] Ibuprofen is readily available as a racemic mixture of two enantiomers, (R) ibuprofen and (S) ibuprofen (RS-ibuprofen). Even though only the (S) enantiomer is the biologically active form, most preparations contain this racemic mixture because the (R) enantiom...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K9/00A61K9/19A61K31/192A61K47/18A61P25/04A61P29/00
CPCA61K9/0019A61K47/183A61K9/19A61K9/0095A61P25/04A61P29/00A61K31/192A61K31/198
Inventor L·帕维利夫
Owner CUMBERLAND PHARM INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com