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Method for extracting astragaloside and polysaccharide from traditional Chinese medicine astragalus and its capsule preparation

A technology of astragaloside IV and its extraction method, which is applied in chemical instruments and methods, pharmaceutical formulations, preparation of sugar derivatives, etc., can solve the problem of polysaccharide components not being retained, and achieve the effects of stable performance, high activity, and improved purity

Inactive Publication Date: 2004-12-29
YANGTZE RIVER PHARM GRP CO LTD
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  • Summary
  • Abstract
  • Description
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AI Technical Summary

Problems solved by technology

This prevents the retention of biologically important polysaccharide components

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1 is that the present invention extracts each component from the traditional Chinese medicine Astragalus membranaceus: take 6.7 kg of Astragalus decoction pieces, add distilled water to decoct 3 times, decoct for 2 hours with 10 times the amount for the first time, and decoct for 2 hours for the second and third times respectively. Double the amount and 6 times the amount of decoction for 1 hour, combine the decoction liquid, filter, the filtrate is concentrated to 2 g of the original medicinal material per 1 ml, precipitate with ethanol to make the amount of ethanol reach 75%, refrigerate overnight, filter, and take the filtrate I and Precipitation I two parts, spare. Filtrate I recovered ethanol and concentrated to a relative density of 1.3-1.4 (20°C), added ethanol and stirred thoroughly to make the ethanol content reach 85%, refrigerated overnight, filtered, recovered ethanol from the filtrate and concentrated to 10g per 1ml equivalent to the original drug...

Embodiment 2

[0017] Embodiment 2 is another method of the present invention to extract various components from the traditional Chinese medicine Astragalus membranaceus: take 6.7 kg of Astragalus decoction pieces, add water to decoct 3 times, decoct for 2 hours with 10 times the amount for the first time, and decoct for 2 hours for the second and third times. Decoct 8 times the amount for 1.5 hours, combine the decoction liquid, filter, concentrate the filtrate to 1 g of the original medicinal material per 1 ml, precipitate with ethyl alcohol to make the ethanol content reach 70%, refrigerate overnight, filter, and separate the filtrate I and precipitate I Two parts, spare. Filtrate I recovered ethanol and concentrated relative density 1.2~1.3 (20°C), extracted 3 times with water-saturated sec-butanol at a volume ratio of 1.5:1, combined sec-butanol, and extracted with 1% NaoH solution at a volume ratio of 2:1 2 times, collect sec-butanol, concentrate to a relative density of 1.2-1.3 (20°C)...

Embodiment 3

[0018] Example 3 is the preparation method of Astragalus capsule preparation: take the above-mentioned astragaloside IV and astragalus polysaccharide extracts, mix them evenly, add an appropriate amount of micropowder silica gel-calcium sulfate (25:7), and make 1000 capsules, each capsule is 0.25g.

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PUM

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Abstract

The present invention relates to the preparation process and capsule preparation of astragaloside an and astragalus polysaccharide. Medicine material astragalus root is processed through water decoction, alcohol precipitation to obtain supernatant, concentration, butyl alcohol or sodium hydroxide solution extraction of the concentrate and decompression recovering to obtain astragaloside A; the alcohol precipitate is dried, water dissolved and alcohol precipitated repeatedly or ethanol washing, and drying to obtain astragalus polysaccharide. The astragaloside an and the astragalus polysaccharide are compounded with or without supplementary material, and the mixture is prepared into capsule. The capsule has the functions of benefiting vital energy, enhancing body resistance and nourishing lung and spleen and is used mainly in treating chronic bronchitis and obstructive pneumonectasis.

Description

Technical field: [0001] The invention relates to an extraction method for extracting astragaloside IV and polysaccharide from traditional Chinese medicine astragali and a capsule preparation thereof. Background technique: [0002] Astragalus single-flavor preparations listed in my country include Radix Astragali ("(Chinese Medicine Prescriptions)" Volume 16, WS 3 -B-3103-98) and Astragalus granules ("(Chinese Medicine Prescriptions" Volume 11, WS 3 -B-2248-96), all adopted the simple percolation method to extract astragaloside IV, and this method, namely poaching, alcohol precipitation and extraction. This prevents the retention of the biologically important polysaccharide components. Modern research shows that astragalus polysaccharides have anti-fatigue, hypoxia, low-temperature, high-temperature, and radiation-resistant experiments on stress response. Experiments on immunopharmacological effects have shown that it can significantly increase the weight of the spleen of a...

Claims

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Application Information

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IPC IPC(8): A61K31/715A61P11/00C07H1/08C07H17/07C08B37/00
Inventor 罗明生陆宏国吴沉张锦锋张国盛
Owner YANGTZE RIVER PHARM GRP CO LTD
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