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Naringin and its salt used for preparing cough suppressing phlegm tramsforming medicine

A technology for relieving cough and reducing phlegm and naringenin, which is applied in the field of preparing naringenin and its salts for relieving cough and reducing phlegm, can solve the problems that there are no reports on the application of naringenin for relieving cough and reducing phlegm, and achieve the effect of relieving cough and reducing phlegm. Rapid and simple extraction process

Active Publication Date: 2004-12-22
广东伯克生物医药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the application of naringenin in relieving cough and reducing phlegm

Method used

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  • Naringin and its salt used for preparing cough suppressing phlegm tramsforming medicine
  • Naringin and its salt used for preparing cough suppressing phlegm tramsforming medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Naringin monomer (purity 97.3%), add 10 times of water, mix evenly, add concentrated hydrochloric acid to make the solution PH = 1, mix evenly; heat and hydrolyze at 100°C for 2 hours; after hydrolysis, filter to obtain crude naringenin ; After five times of recrystallization with absolute ethanol, naringenin monomer was obtained. The yield was 91.4%.

Embodiment 2

[0035] For crude naringin (purity 98.2%), add 20 times of water, mix evenly, add concentrated sulfuric acid to make the solution pH = 0, mix evenly; heat and hydrolyze at 80°C for 3 hours; after hydrolysis, filter to obtain crude naringenin; After six times of recrystallization with ethyl acetate, naringenin monomer was obtained. The yield was 89.3%.

Embodiment 3

[0037] Crude naringin (purity 98.5%), add 50 times of water, mix evenly, add sodium hydroxide solution to make the solution PH = 13, mix evenly; heat and hydrolyze at 80°C for 1.5 hours; after hydrolysis, filter to obtain naringenin Crude product; after three times of recrystallization with acetone, naringenin monomer was obtained. The yield was 86.9%.

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Abstract

An application of naringenin and its salt in preparing the medicines for treating cough and resolving phlegm is disclosed. Said naringenin is prepared from naringin through hydrolysis or from the natural medicinal materials through extracting, or by chemical synthesis. Its advantages are high curative effect and no toxic by-effect.

Description

technical field [0001] The present invention relates to the use of naringenin (Naringenin) and its salt for preparing medicine for relieving cough and reducing phlegm. Background technique [0002] Cough, sputum, and wheezing are common symptoms of respiratory diseases. They are especially common in daily life caused by acute and chronic bronchitis, colds, etc. Clinically, cough, sputum, wheezing and recurrent attacks are characterized by infection or Acute and chronic non-specific inflammation of the trachea, bronchial mucosa and surrounding tissues caused by non-infectious factors. It belongs to the category of cough, phlegm retention, and asthma in traditional Chinese medicine, and is a common and frequently-occurring disease. Especially middle-aged and elderly people are prone to bronchitis symptoms such as cough and expectoration due to the influence of environmental factors and living habits. They are not well treated and controlled in the early stage of the disease, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/20A61K9/72A61K31/353A61P11/10A61P11/14
Inventor 苏薇薇王永刚方铁铮彭维吴忠
Owner 广东伯克生物医药有限公司
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