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Ranitidine hydrochloride capsule producing process

A technology of ranitidine hydrochloride and production process, which is applied in the field of production technology of ranitidine hydrochloride capsules, can solve the problems of slow dissolution, influence on drug absorption, influence on drug efficacy and the like

Inactive Publication Date: 2004-04-14
雅来(佛山)制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The above-mentioned binder is used to granulate, so that the surface of the drug granules is covered with a layer of adhesive film, so when the drug granules are dissolved in water, the film must be dissolved first, and then the drug is dissolved, so the dissolution of the drug granules in water is slowed down. Even affect the absorption of drugs in the body and thus affect the efficacy of drugs

Method used

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  • Ranitidine hydrochloride capsule producing process
  • Ranitidine hydrochloride capsule producing process
  • Ranitidine hydrochloride capsule producing process

Examples

Experimental program
Comparison scheme
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Embodiment Construction

[0010] see figure 1 , the prescription of the present embodiment production technology is:

[0011] Name of raw and auxiliary materials Sieve size (mm / mesh) Consumption per 10,000 grains (kg)

[0012] Ranitidine hydrochloride 1.3 / 14 1.70

[0013] Starch 0.30 / 60 0.87

[0014] 75% ethanol filter 0.172

[0015] Magnesium stearate 0.44 / 40 0.02056

[0016] Process specification

[0017] 1. Processing of raw and auxiliary materials:

[0018] 1. Raw materials of ranitidine hydrochloride are processed through a 14-mesh sieve and set aside. The starch is processed through a 60-mesh sieve and set aside. Magnesium stearate is processed through a 40-mesh sieve for subsequent use.

[0019] 2. Weigh ethanol and add the calculated amount of deionized water to make a 75% ethanol solution for later use.

[0020] 2. Granulation:

[0021] 1. Weigh the prescribed amount of ranitidine hydrochloride and starch, alternately put them into the batching pot of the wet mixing granulator, close...

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PUM

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Abstract

The invention discloses a Ranitidine hydrochloride capsule producing technique, raw material being Ranitidine hydrochloride, assistant material being amylum, and lubricant being magnesium stearate. Mix raw and assistant materials to make particles, then dry to mix evenly, add in the lubricant, and finally capsulize to make the finished product. After mixing raw and assistant materials, add in 50-95% alcohol solution as wetter replacing bond, to make particles, so as to make the particles looser, extremely easy to dissolve in water and having fluidity.

Description

technical field [0001] The present invention relates to the technology of pill capsule, especially the production technology of ranitidine hydrochloride capsule. Background technique [0002] Ranitidine Hydrochloride Capsules is a histamine receptor blocker, which is widely used clinically to treat gastric ulcer, duodenal ulcer and reflux esophagitis. The production process of traditional ranitidine hydrochloride capsules: [0003] <chemistry num="001"> <chem file="03140044_cml001.xml" / > < / chemistry> [0004] <chemistry num="002"> <chem file="03140044_cml002.xml" / > < / chemistry> [0005] Among them, the binders used include starch slurry, syrup, methyl cellulose and its derivatives, synthetic resin PVP and the like. The above-mentioned binder is used to granulate, so that the surface of the drug granules is covered with a layer of adhesive film, so when the drug granules are dissolved in water, the film must be dissolved first, a...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/341A61P1/04
Inventor 刘凯列
Owner 雅来(佛山)制药有限公司
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