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Researching and preparing method for new Chinese medicine

A technology of traditional Chinese medicine and new medicine, applied in the direction of pharmaceutical formula, medical preparations containing active ingredients, unknown raw materials, etc., can solve the problems of difficult development, long cycle, and no source yet, and achieve the effect of identification and optimization of compatibility ratio

Inactive Publication Date: 2004-02-11
ZHEJIANG UNIV
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Problems solved by technology

A class of traditional Chinese medicines are monomers obtained from plants, which are similar to western medicines and can learn from the theories and methods of developing new medicines of western medicines, but the development is difficult, costly and takes a long time
The second type of Chinese medicine is the effective part or effective part group. As far as the current situation is concerned, most of them are effective parts extracted from single medicinal materials, and there are a few injections. There are no secondary drugs derived from compound effective parts or effective part groups. New Chinese medicine
As we all know, compound prescriptions are the main method of traditional Chinese medicine. The unique curative effect of traditional Chinese medicine can only be reflected through rationally formulated prescriptions. The development of traditional Chinese medicine only from single medicinal materials cannot reflect the characteristics of traditional Chinese medicine. However, the development of new drugs from compound prescriptions, More likely to get Chinese medicine that conforms to traditional Chinese medicine theory

Method used

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Examples

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Effect test

Embodiment 2

[0025] Example 2: Design and optimize new lipid-lowering drugs from the refined Xuefu Zhuyu formula

[0026] Xuefu Zhuyu Prescription is a famous classic prescription, and it is also the main prescription of traditional Chinese medicine for treating atherosclerosis. One of its mechanisms of action is to treat atherosclerosis by improving lipid metabolism. The simplified and refined Xuefu Zhuyu Prescription is: Chuanxiong: 1.5-4.8 grams; Chishao: 1.5-4.8 grams; Peach Kernel: 1.5-4.8 grams; Safflower: 1.5-4.8 grams; Fructus Aurantii: 1.0-3.2 grams ; Bupleurum 0.5 ~ 1.6 grams.

[0027] 1. Extraction and separation:

[0028] Add 10 times the amount of water to the whole recipe, decoct 3 times, 2 hours each time. Combine the decoction extracts, filter, and concentrate the filtrate into an extract. The extract is separated with D-101 type macroporous resin, and is separated with water, 10% ethanol, 20% ethanol, 30% ethanol, 40% ethanol, 50% ethanol, 60% ethanol, 70% ethanol, 80% ...

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Abstract

The Chinese medicine developing process includes selecting traditional Chinese recipe with determined curative effect, separating the components, optimizing the component combination, determining thescreening model and performing medicine effect test based on Chinese medicinal theory and compound Chinese medicine features, computer aided analysis to recognize effective components, combining modeand medicinal effect, and optimizing new Chinese medicine. The said process can raise the screening efficiency of effective components, shorten screening period and embody compound Chinese medicine features. Altering the combination mode of medical herb pieces into combination of effective components develops modern Chinese medicine preparation with clear matter basis and controllable quality, being safe and effective and coinciding with international standard.

Description

technical field [0001] The present invention relates to the field of research and development of new traditional Chinese medicines, in particular to methods for the development of new traditional Chinese medicines. Specifically, traditional Chinese medicine compound prescriptions are taken as the research object, effective components are screened, new prescriptions are formed by means of component compatibility, and the research and development conforms to international norms. Class I and Class II new drugs of traditional Chinese medicine. Class II new drug. Background technique [0002] Since ancient times, traditional Chinese medicine compound prescriptions have been in the form of compatibility of decoction pieces, and the selection of prescriptions and medications conforms to the theory of TCM syndrome differentiation and treatment and the law of compatibility of monarchs, ministers, assistants and envoys. The composition of traditional Chinese medicine compound is by n...

Claims

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Application Information

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Inventor 程翼宇栾连军邵青吴永江王毅史大卓张伯礼王永炎
Owner ZHEJIANG UNIV
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