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Medicinal collagen material and its making process

A collagen and manufacturing process technology, which can be used in medical preparations containing active ingredients, peptide/protein components, animal/human proteins, etc., and can solve problems such as inability to apply, unstable molecular structure, and short degradation time.

Inactive Publication Date: 2003-12-31
于海鹰 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Because the molecular structure of medical collagen products prepared by the above-mentioned traditional methods is not stable enough, the leakage resistance is poor, and the degradation time in human tissues is short, it cannot be applied to certain fields that have higher requirements for the performance of such products

Method used

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Examples

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Embodiment Construction

[0004] Specific embodiments of the present invention are as follows:

[0005] 1. Carry out impurity removal, cleaning, acid treatment, alkali treatment, salt treatment, and protease enzymatic hydrolysis on animal connective tissue according to traditional methods to obtain medical collagen semi-finished product homogenate. Since the traditional methods are known techniques that have been used for many years, No further details are given here.

[0006] 2. Place the obtained medical collagen semi-finished product homogenate in a stirrer, stir at 2-15°C for 30-180 minutes, then add chondroitin sulfate dropwise at a concentration ratio of 0.2-0.5% for 10-10 minutes 60 minutes, and then continue to stir for 30 to 180 minutes.

[0007] 3. Put the above medical collagen semi-finished product into a special molding device, put it in a freezer vacuum dryer with a vacuum degree of 200-900 millitorr, and freeze it at a temperature of -55-35°C for 1-2 hours, and then put it in the machin...

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Abstract

The medical collagen material is made through the processes of chondroitin sulfate crosslinking, high temperature vacuum drying and ethylene oxide. Is has stable molecule structure and better anti-seepage and anti-stick performance, and is used in repairing cerebral dura mater, spinal dura mater and peripheral nerve.

Description

technical field [0001] The invention relates to a medical collagen material and a manufacturing process thereof, in particular to a medical collagen material and a manufacturing process that can be used for repairing dura mater, dura mater and peripheral nerves. technical background [0002] In recent years, the research and clinical application of collagen-based products in the medical field are on the rise, especially collagen medical products in the form of films or sponges have achieved significant development. At present, the preparation of such medical collagen products basically continues to use animal connective tissue, especially bovine tendon, as raw materials, after impurity removal, cleaning, acid-base treatment and salt treatment, protease enzymatic hydrolysis, chemical cross-linking, low-temperature drying, forming and encapsulation, Obtained by γ-ray sterilization and other processes, the main body of the product is type I collagen. T...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K38/39A61L33/12A61P41/00C07K14/78
Inventor 于海鹰
Owner 于海鹰
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