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Collagen material and its producing method

A collagen material, collagen technology, applied in the direction of non-woven fabrics, textiles and papermaking, packaging food, etc., can solve problems such as difficult to manipulate materials, opacity of polyethylene glycol acid, etc.

Inactive Publication Date: 2003-09-10
清水庆彦 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, polyethylene glycol acid is difficult to use to manipulate materials by itself because it is opaque

Method used

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  • Collagen material and its producing method
  • Collagen material and its producing method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0085] A 1N hydrochloric acid solution (collagen concentration 1 wt %) for extracting collagen was formulated with collagen obtained from pig skin, and poured into a petri dish to form an 18 mm thick collagen solution layer. This was frozen at -20°C for 24 hours, followed by lyophilization at -80°C for 48 hours. Then carry out thermal dehydration and cross-linking at 140 DEG C for 24 hours under vacuum with the multidimensional structure body (hereinafter referred to as the multidimensional structure body) of this freeze-dried collagen fiber, and then use a glass water pump to make the inside of the multidimensional structure body form a negative pressure ( 50cm water column), and then introduce the 1N hydrochloric acid solution (collagen concentration 0.5wt%) of extracting collagen into this multidimensional structure, so that the gaps inside the multidimensional structure are embedded in non-fibrillated collagen, and then under the same conditions as described , freeze and f...

Embodiment 2

[0093] The collagen material of the present invention was obtained in the same manner as in Example 1 except that the collagen solution layer was formed five times on the compressed material. With regard to the collagen material, the point support tension and tensile strength in dry and wet states were measured by the same method as in Example 1. The results are listed in Table 1.

Embodiment 3

[0095] Except between the second freeze-drying operation and the compression operation, the operation of reducing the voids inside the multidimensional structure through thermal dehydration cross-linking treatment and newly forming fibrous collagen under the same conditions as described above and the Except that the compressed material was not subjected to the operation of forming a collagen solution layer, the point support tension and tensile strength in dry and wet states were measured according to the same method. The results are listed in Table 1.

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Abstract

The objective of the present invention is to provide a collagen material that possesses physical properties to an extent that allows suturing while still maintaining the biochemical properties inherently possessed by collagen, and retains its shape for a certain amount of time even after application to the body; its production process; and, a medical material on which it is based, examples of which include a artificial tube for nerve, artificial tube for spinal cord, artificial esophagus, artificial trachea, artificial blood vessel, artificial valve or alternative medical membranes such as artificial endocranium, artificial ligamenta, artificial tendons, surgical sutures, surgical prostheses, surgical reinforcement, wound protecting materials, artificial skin and artificial cornea, characterized by filling or having inside a substance having biocompatibility that can be degraded and absorbed in the body into a matrix of a non-woven fabric-like multi-element structure of collagen fibers having ultra-fine fibers of collagen as its basic unit.

Description

technical field [0001] The present invention relates to the matrix of non-woven multi-layer body made of collagen super (micro) fine fibers, or in the matrix of non-woven fabrics which have both biocompatibility and can be degraded and absorbed in the body. A collagen material that is biocompatible and capable of degrading and absorbing substances in a living body, a material containing the collagen material in a specific form, a medical material formed from the material, and a preparation method thereof. Background technique [0002] Among the various raw materials used as medical materials, collagen derived from animals has excellent bioaffinity and histocompatibility, low antigenicity, and has the effect of promoting host cell differentiation and proliferation, and has hemostatic effect. It can be completely degraded and absorbed in the body, so it has the most excellent characteristics as a raw material for medical materials. Collagens from animals have been found to be...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L15/32A61L17/08A61L26/00A61L27/24A61L31/04D04H1/42D04H1/64
CPCA61L17/08A61L27/24D04H1/42A61L26/0033Y10S623/915A61L15/325Y10S514/801Y10S623/917D04H1/643A61L31/044D04H1/4266Y10T442/614Y10T442/608Y10T442/2525A61L27/60A61L15/64A61L15/225A61L27/58A61L27/507A61L27/40A61L27/26A61L31/148A61L31/12A61L31/041A61L15/42
Inventor 清水庆彦
Owner 清水庆彦
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