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Medicinal composition containing calcium and iron elements

A technology of composition and iron element, which is applied in the direction of drug combination, medical preparation containing active ingredients, pharmaceutical formula, etc. Improves hemoglobin level, prevents pregnancy poisoning, and promotes growth and development

Inactive Publication Date: 2003-04-16
北京海王中新药业股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are many types of calcium supplements available in the market, but they generally have three defects: low solubility, low calcium content and low absorption
Many iron supplements have side effects such as gastrointestinal reactions and constipation
And when calcium supplement and iron supplement are taken orally at the same time, there is another technical problem: in terms of chemical structure, calcium and low-priced iron (ferrous iron) are all divalent cations, which contradict and antagonize each other in the process of absorption and metabolism in the body. , so that the absorption and utilization of calcium and iron are very low

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0012] Example 1 Preparation of calcium-iron composite tablets

[0013] Weigh the three raw materials according to the weight ratio of "psoralen: calcium citrate malate coordination compound: iron glycinate coordination compound = 1400:40:1", pulverize the psoralen, pass through a 120-mesh sieve, and mix with citric acid. The calcium citrate malate coordination compound and the iron glycinate coordination compound are mixed uniformly, and conventional auxiliary materials such as excipients are added. Rolled into pieces. The daily oral dose is equivalent to 14 g of crude drug psoralen, 300 mg of calcium citrate malate coordination compound, and 10 mg of iron glycinate coordination compound.

Embodiment 2

[0014] Example 2 Preparation of calcium-iron composite capsules

[0015] Weigh the three raw materials according to the weight ratio of "psoralen: calcium citrate malate coordination compound: iron glycinate coordination compound = 1500:36:1", and decoct the psoralen for 3 times, each for 2 hours , The decoction liquid is concentrated, dried and crushed to obtain fine powder, mixed with the calcium citrate malate coordination compound and the iron glycinate coordination compound, and the finished product is filled into capsules. The daily oral dose is equivalent to 15 g of crude drug psoralen, 360 mg of calcium citrate malate coordination compound, and 10 mg of iron glycinate coordination compound.

Embodiment 3

[0016] Example 3 Preparation of calcium-iron complex nutritional oral liquid (syrup) formula: psoralen 1400g, calcium citrate malate coordination compound 30g, glycinate iron coordination compound 1g amino acid 5g, honey 100g sugar 250g, citric acid 2g, and appropriate amount of flavor.

[0017] Preparation:

[0018] 1. Add psoralen and boil for 3 times, the first time is 2 hours, the second time is 1.5 hours, and the third time is 1 hour. Combine the decoction, filter, concentrate the filtrate to about 1 liter, let cool, add 1.5 liters of ethanol, stir well, let stand for 24 hours, filter, and concentrate the filtrate under reduced pressure to an extract shape, dilute with an appropriate amount of water, and filter. spare.

[0019] 2. Dissolve granulated sugar in water, filter to a concentration of 65%, sterilize, and cool to below 30°C. Add honey, amino acids, citric acid, psoralen extract, calcium citrate malate coordination compound, iron glycinate coordination compound, flavo...

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PUM

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Abstract

A medical composition containing Ca and Fe elements without antagonism is prepared from malaytea scurfpea fruit (1200-1600 portions), coordination compound of calcium malate citrate (10-200), and coordination compound of iron glycinate (1).

Description

(1) Technical field [0001] The invention belongs to a pharmaceutical composition containing both calcium and iron, and is used for the treatment and prevention of diseases caused by calcium and / or iron deficiency. (2) Background technology [0002] Calcium and iron have important physiological and biochemical functions for the human body, and are important factors for the human body to maintain health. At the same time, calcium and iron play an important role in the occurrence, development and outcome of various diseases in the human body. Unfortunately, calcium and iron deficiencies are common in natural populations, and often deficiencies of both elements occur at the same time. Some special populations (such as the elderly, children, pregnant women, breastfeeding women) lack of calcium and iron are more common, leading to the occurrence of many diseases. From a nutritional point of view, an adequate supply of calcium and iron is very important for the growth and development of...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61P3/02
Inventor 马永华
Owner 北京海王中新药业股份有限公司
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