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Chitosan medical nerve and productive method thereof

A production method and technology of chitosan are applied in the field of medical neurology to achieve the effects of good elasticity and good biocompatibility

Inactive Publication Date: 2002-12-18
NANTONG UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Chinese patent document CN1319379A discloses a medical artificial nerve graft and its production method, but because it contains foaming agent, cross-linking agent, surfactant and other ingredients, the product has certain side effects

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0016] (1) Preparation of chitosan tube: be that 85-90% (example 85%, 88%, 90%) have certain viscosity chitosan 5 grams to be dissolved in 50-150ml (example 50ml, 100ml, 150ml) weak acid solution, used weak acid is acetic acid (or phosphoric acid, citric acid, lactic acid), and the concentration of acid is 2%-15% (example: 2%, 7%, 12%, 15%). After the chitosan is fully dissolved, let it stand for about 3 hours. Then the solution is passed through a tubular forming die, and molded in an alkaline coagulation solution—sodium hydroxide coagulation solution, for molding processing. Used coagulation solution is to contain sodium hydroxide 8%-20% (example 8%, 13%, 17%, 20%), containing ethanol 5%-30% (example: 5%, 15%, 25%, 30%) simultaneously )The solution. After molding, the catheter is fully soaked in distilled water to remove inorganic salts of sodium acetate, sodium phosphate or sodium lactate in the chitosan.

[0017] (2) The preparation of chitosan fiber support: be that 85...

Embodiment 2

[0021] Sodium hydroxide coagulation liquid adopts the solution that contains sodium hydroxide 8~20% (example 8%, 13%, 17%, 20%). All the other are with embodiment 1.

Embodiment 3

[0023] Alkaline coagulation liquid is to contain potassium hydroxide 8%-20% (example 8%, 13%, 17%, 20%), containing ethanol 5%-30% (example: 5%, 15%, 25%, 30% simultaneously) %)The solution. All the other are with embodiment 1.

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Abstract

The present invention discloses a kind of chitosan medical nerve, including chitosan bio-catheter and chitosan fibre scaffold inserted into the chitosan bio-cathether. Its production method includes the preparation of the above-mentioned materials and their combination steps. It is a pure natural bio-degradable material, so that it possesses good bio-compatibility, has no any adverse reaction. Itthe course of preparation is does not add any foaming agent, cross-linking agent and surfactant, therefore said product contains no any exogeneous toxic substances capable of producing said effect.

Description

Technical field: [0001] The invention relates to a medical nerve for bridging defective nerves. Background technique: [0002] Peripheral nerve defect is a difficult problem in the treatment of orthopedics, microsurgery, trauma surgery, and war surgery. Although modern microsurgical techniques are highly accurate, the functional recovery rate after peripheral nerve injury repair is still not satisfactory. Chinese patent document CN1319379A discloses a medical artificial nerve graft and a production method, but because it contains ingredients such as foaming agent, cross-linking agent, and surfactant, the product has certain side effects. Invention content: [0003] The object of the present invention is to provide a chitosan medical nerve without any exogenous toxic and side effect substances and its production method. [0004] Technical solution of the present invention is: [0005] A chitosan medical nerve is characterized in that it comprises a chitosan biological con...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/20
Inventor 杨宇民顾晓松王晓东张沛云丁斐吴启运严志强
Owner NANTONG UNIVERSITY
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