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Method of determining potential susceptibility to development of ALTE and/or SIDS

A susceptibility and potential technology, used in measurement devices, biological testing, material inspection products, etc.

Inactive Publication Date: 2002-06-12
纽卡塞尔大学研究合伙有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] However, to date, there is no method based on specific immunoassays to predict potential susceptibility to ALTE and / or SIDS

Method used

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  • Method of determining potential susceptibility to development of ALTE and/or SIDS
  • Method of determining potential susceptibility to development of ALTE and/or SIDS
  • Method of determining potential susceptibility to development of ALTE and/or SIDS

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0040] Total IgA, IgG and IgM levels in saliva of ALTE infants

[0041] saliva collection

[0042] Completely mixed saliva was collected from the cheek of the mouth by gentle sucking [15]. This method can be used successfully in children (over 1 day old) and adults [1,16].

[0043] Questionnaire

[0044] SIDS-related demographic data were collected using standard questionnaires. They were classified into the "narrowly escaped" SIDS group (ALTE) by the attending pediatrician based on clinical observations.

[0045] saliva test

[0046] Salivary immunoglobulins were determined by ELISA and albumin by rate nephelometric assay (Beckman. ARRAY) [16].

[0047] Statistical analysis

[0048] Differences in mucosal immune parameters between ALTE infants and two control groups (mild URTI and healthy infants) were determined using analysis of variance (ANOVA) or appropriate nonparametric statistics.

[0049] object

[0050]Thirty-seven infants (20 males, 17 females) aged 1-10 mon...

Embodiment 2

[0083] Total IgA and IgA1 subclasses in saliva of ALTE infants

[0084] research group

[0085] Saliva samples were collected on the day of admission of infants with unexplained life-threatening acute exacerbation (ALTE). These infants were included in the study if congenital or obstructive causes of asphyxia were ruled out. This group of subjects is categorized as "Nearby SIDS" infants.

[0086] Saliva was collected from two groups of age-matched subjects. Normal healthy infants from the Child Immunization Clinics were recruited and classified as healthy infants. A second group was recruited from general practitioners, called infants with mild upper respiratory tract infection, who were classified as a mildly infected control group. Saliva was collected on the day of the mild infection visit.

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Abstract

The present invention relates to methods for determining predisposition to apparent life-threatening events (ALTE) (also referred to as ''acute life threatening episodes'') and / or sudden infant death syndrome (SIDS) and in particular to methods of assessing potential susceptibility to development of ALTE and / or SIDS by determining a subject's total IgA and / or IgA1 level.

Description

field of invention [0001] The present invention relates to methods for determining susceptibility to life-threatening acute exacerbation (ALTE) and / or sudden infant death syndrome (SIDS), in particular to assess potential susceptibility to developing ALTE and / or SIDS by measuring total IgA and / or IgAl in a subject Methods. Background of the invention [0002] Much effort has been made to minimize the risk of SIDS involving infant care through nonspecific approaches. However, methods of prevention using specific tests involving etiological mechanisms have not been developed to date. With routine awareness and if used in conjunction with nonspecific care, it is expected that the identification of etiological mechanisms will have an important impact on the outcome of SIDS. Developing new methods to identify infants at risk of SIDS could have a very significant impact. [0003] Interest in methods of preventing SIDS was aroused by the occasional observation of "predicted" cas...

Claims

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Application Information

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IPC IPC(8): G01N33/53G01N33/50G01N33/68
CPCG01N33/6854G01N33/53
Inventor R·克兰西M·格利森
Owner 纽卡塞尔大学研究合伙有限公司
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