Nose cavity administering formulation of nalmefene
A technology for nasal administration and nalmefene, which is applied in the direction of drug combinations, pharmaceutical formulas, and medical preparations containing active ingredients, etc. It can solve the problems of slow onset of action and achieve stable performance and controllable quality
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Embodiment 1
[0034] Embodiment 1: Nalmefene hydrochloride spray
[0035] Ingredient Amount
[0036] Nalmefene Hydrochloride 80mg
[0037] Polyvinylpyrrolidone 0.5g
[0038] Laurazone 0.5ml
[0039] Propylene glycol 1.0g
[0040] Ethylparaben 0.1g
[0041] Distilled water to 100ml
[0042] Preparation method: fully stir the above-mentioned amount of polyvinylpyrrolidone, nalmefene hydrochloride, propylene glycol, and lauryl nitrogen statistical ethylparaben to dissolve them all, and finally add distilled water to 100ml. The obtained solution is distributed in a spray pump or a quantitative drop pump.
Embodiment 2
[0043] Embodiment 2: Nalmefene hydrochloride spray
[0044] Ingredient Amount
[0045] Nalmefene Hydrochloride 80mg
[0046] Hydroxypropyl-β-cyclodextrin 2.5g
[0047] Ethylparaben 0.1g
[0048] Mannitol 0.5g
[0049] Macrogol 400 1.0ml
[0050]Distilled water to 100ml
[0051] Preparation method: shake the above amount of nalmefene hydrochloride, hydroxypropyl-β-cyclodextrin, ethylparaben, mannitol and distilled water to dissolve, add the above polyethylene glycol 400, and finally add distilled water to 100ml.
Embodiment 3
[0052] Embodiment 3: Nalmefene hydrochloride spray
[0053] Ingredient Amount
[0054] Nalmefene Hydrochloride 160mg
[0055] Methyl-beta-cyclodextrin 5g
[0056] Ethylparaben 0.1g
[0057] Polyvinyl alcohol 0.5g
[0058] Mannitol 2-4g
[0059] Distilled water to 100ml
[0060] Preparation method: add distilled water to the above amount of nalmefene hydrochloride, methyl-β-cyclodextrin, ethylparaben, polyvinyl alcohol, shake to dissolve all, and finally add distilled water to 100ml.
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