Dogwood extraction and its preparation method and usage
A technology of extract and cornus, applied in the field of cornus extract, can solve the problems such as prevention and treatment of diabetic vascular disease that have not been seen with cornus extract, and achieve the effects of improving the morphological and pathological changes of vascular endothelium and kidney tissue, reducing the amount of excretion and lowering blood sugar.
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Embodiment 1
[0096] 1000 g of Cornus officinalis medicinal material was reflux extracted with ethanol for 3 times, the ethanol concentration was 70%, the amount of alcohol added was 15 times of the weight of the medicinal material, the extraction time was 120 min, and the extraction temperature was 80°C. The extracts were combined, filtered and concentrated under reduced pressure. The concentrated solution was added with 4 times the amount of water to precipitate and then centrifuged. The precipitate was collected and dried under reduced pressure, crushed to obtain extract A, and the centrifuged supernatant was concentrated under reduced pressure for later use.
[0097] Take the non-polar macroporous adsorption resin, pack it into a column at a ratio of 1:1 to the weight ratio of the crude drug, and then pass the above-mentioned concentrated solution for use through the macroporous resin column at a flow rate of 1 column volume / hour. Deionized water was used for elution, followed by gradien...
Embodiment 2
[0100] 1000 g of Cornus officinalis medicinal material was reflux extracted twice with ethanol, the ethanol concentration was 85%, the amount of alcohol added was 12 times of the weight of the medicinal material, the extraction time was 90 min, and the extraction temperature was 75°C. Combine the extracts, filter and concentrate under reduced pressure, add 5 times the amount of water to the concentrate to precipitate, then centrifuge, collect the precipitate, dry it under reduced pressure, pulverize to obtain extract A, and concentrate the supernatant under reduced pressure for future use.
[0101] Take a medium-polarity macroporous adsorption resin, pack it into a column at a ratio of 1:2 to the weight ratio of the crude drug, and then pass the above-mentioned standby concentrated solution through the macroporous resin column at a flow rate of 1.5 column volume / hour. After passing through completely, use Deionized water was used for elution, followed by gradient elution with 5...
Embodiment 3
[0104] 1000 g of cornus officinalis is crushed and passed through a 40-mesh sieve, impregnated with 20% ethanol for 48 hours, and then extracted by percolation at a flow rate of 4-5 ml / min, and the percolation amount is 10 times the weight of the medicinal material. The extracts were combined, filtered and concentrated under reduced pressure. The concentrated solution was added with 4 times the amount of water to precipitate and then centrifuged. The precipitate was collected and dried under reduced pressure, crushed to obtain extract A, and the centrifuged supernatant was concentrated under reduced pressure for later use.
[0105] Take a medium-polar macroporous adsorption resin, pack it into a column at a ratio of 1:3 to the weight ratio of the crude drug, and then pass the above-mentioned concentrated solution for use through the macroporous resin column at a flow rate of 1 column volume / hour. After passing through completely, use Deionized water was used for elution, follow...
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